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Craniopharyngioma: Intracranial Pressure | PDF | Endocrinology | Cell Biology
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Craniopharyngioma: Intracranial Pressure

This document discusses craniopharyngioma, a type of brain tumor. It first notes that remnants of the craniopharyngeal duct can be found in the suprasellar region. It then explains that mutations in the CTNNB1 gene, which encodes beta-catenin, can lead to abnormal accumulation of beta-catenin and overactivation of the Wnt signaling pathway. This dysregulation of transcription can result in cell hyperplasia and the formation of craniopharyngioma. Symptoms include necrosis and cyst formation that increase intracranial pressure, as well as calcium deposition that can cause blurred vision or multiple pituitary hormone deficiencies.

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Gabriela Grace Sinaga
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98 views1 page

Craniopharyngioma: Intracranial Pressure

This document discusses craniopharyngioma, a type of brain tumor. It first notes that remnants of the craniopharyngeal duct can be found in the suprasellar region. It then explains that mutations in the CTNNB1 gene, which encodes beta-catenin, can lead to abnormal accumulation of beta-catenin and overactivation of the Wnt signaling pathway. This dysregulation of transcription can result in cell hyperplasia and the formation of craniopharyngioma. Symptoms include necrosis and cyst formation that increase intracranial pressure, as well as calcium deposition that can cause blurred vision or multiple pituitary hormone deficiencies.

Uploaded by

Gabriela Grace Sinaga
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Remnants of Craniopharyngeal Duct occuying

suprasellar region

Mutation in CTNNB1 that encode Beta-Catenin

Abnormal cytoplastic and nuclear


accumulation of Beta-Catenin

Overactivation of Wnt signalling pathway

Abnormal transcription of DNA

Cell hyperplasia

Craniopharyngioma

Necrotic of debris in cyst ⬆ ️ Intracranial Pressure

⬆ ️ Calcium deposition Optic Chiasma Anterior Pituitay

Calcification
Blurred Vision Multiple Pituitary Hormone Deficiency (MPHD)

GH ⬇ ️ GnRH ⬇ ️

FSH ⬇ ️ LH ⬇ ️
Protein synthesis⬇ ️ IGF1⬇ ️ Decreased fat utilization

Abdominal fat accumulation Spermatogenesis ⬇ ️ Testosterone ⬇ ️


Keratin protein cell⬇ ️ ⬇ ️ Chondrocytic cells

Trunkal obesiy Testicular Volume ⬇ ️ Low Secondary Sexual


Poor nail growth ⬇ ️ Bone formation Weight ⬆ ️
Characteristic

Short stature Delayed Bone age Axillary hair ❎ Small Phallus Pubic Hair ❎

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