KEMBAR78
Lupus Anticoagulant Profile Testing Algorithm | PDF | Coagulation | Blood
Scribd
Upload
272 views1 page

Lupus Anticoagulant Profile Testing Algorithm

The document describes a testing algorithm for evaluating a lupus anticoagulant profile. It involves initial testing with prothrombin time, activated partial thromboplastin time, and dilute Russell viper venom time. Follow up tests are then determined based on the results of the initial tests and can include thrombin time, reptilase time, and platelet neutralization procedure to further evaluate evidence of anticoagulation or coagulation factor deficiencies.

Uploaded by

salamon2t
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
272 views1 page

Lupus Anticoagulant Profile Testing Algorithm

The document describes a testing algorithm for evaluating a lupus anticoagulant profile. It involves initial testing with prothrombin time, activated partial thromboplastin time, and dilute Russell viper venom time. Follow up tests are then determined based on the results of the initial tests and can include thrombin time, reptilase time, and platelet neutralization procedure to further evaluate evidence of anticoagulation or coagulation factor deficiencies.

Uploaded by

salamon2t
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Lupus Anticoagulant Profile Testing Algorithm

ALUPP / Lupus Anticoagulant Profile, Plasma


Testing begins with:
■ Prothrombin time (PT)

■ Activated partial thromboplastin time (APTT)

■ Dilute Russell viper venom time (DRVVT)

PT: 9.4-13.9 seconds PT: ≥14.0 seconds PT: ≥14.0 seconds APTT: >37 seconds DRVVT: ≥1.20
APTT: 25–37 seconds OR
DRVVT: <1.20 APTT: >37 seconds
OR
PT Mix 1:1 APTT Mix 1:1 DRVVT Mix ≥1.20 DRVVT Mix <1.20
DRVVT: ≥1.20
DRVVT Confirm ≥1.20 DRVVT Confirm <1.20
≥14.0 <14.0
OR OR
DRVVT Mix <1.20* DRVVT Mix ≥1.20
DRVVT Confirm ≥1.20 DRVVT Confirm <1.20
■ No evidence of lupus-like Thrombin Evidence of Evidence of coagulation Evidence of inhibition
anticoagulant time (bovine) inhibition** factor deficiency**
■ No further testing performed
No evidence of
heparin in sample Not diagnostic of
15.8–24.9 seconds >24.9 seconds lupus anticoagulant
Suggestive of
coagulation factor
Normal–no evidence Reptilase time Platelet neutralization deficiency or
of heparin or dys/ procedure (PNP) anticoagulation
hypofibrinogenemia effect**
Does not Shortens by
shorten 4–5 seconds
14.0–23.9 seconds >23.9 seconds

Anticoagulant effect*** Possible dys/ Possible factor inhibitor Probable lupus anticoagulant
hypofibrinogenemia** but does not exclude if anticoagulation effect can
lupus anticoagulant** be excluded**

*Weak lupus anticoagulant may not inhibit DRVVT Mix


** Additional assays may be performed if further clarification or confirmation is necessary based on preliminary review. These may include:
• Coagulation Factor Assays • Bethesda Units • Fibrinogen • Soluble Fibrin Monomer
• Coagulation Factor Inhibitor Screen • Staclot Lupus Anticoagulant • D-Dimer • von Willebrand Factor Assays

*** Unfractionated/low-molecular weight heparin or direct thrombin inhibitor (eg, dabigatran, argatroban) warfarin or low concentration
of direct anti-Xa inhibitor (eg, rivaroxaban, apixaban, or edoxban)

An interpretive report is included with this profile. If any tests are abnormal, all results will be reviewed by a coagulation consultant.

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 04/2020

You might also like