Basic Human Pathology: Parts I and II

Academic Year 2007/2008

H & E stained photomicrograph of acute inflammation response 5 hours after

Highlights of this Course

This course, Basic Human Pathology, includes the teaching of both general and systemic (organs) pathology. It provides a
basis for other Tufts Dental School courses such as Oral and Maxillofacial Pathology, Oral Diagnosis, Medicine II/III, Oral
and Maxillofacial Surgery, and other clinical science courses. It is a transition course between the other basic science
courses and the clinical sciences of dentistry. Not only does it serve as a foundation course, its knowledge base will also
aid in the understanding of managing patients with complex medical histories, particularly now that patients are living
longer and continue to seek regular dental care.

Course Description

Basic Human Pathology (BHP) is divided into two parts. Part I, general pathology, refers to the study of basic pathology
processes that underlie all disease such as cellular pathology, inflammation and repair, fluid and hemodynamic
derangements, neoplasias, and the study of genetic immunologic, metabolic and deficiency, infections, environmental,
pediatric and geriatric diseases. Part II, systems pathology, refers to the study of diseases affecting specific organs and
their systems such as cardiovasuclar; respiratory; ear, nose, throat; ophthalmic; alimentary tract including oral cavity;
lymphoid and hemopoietic tissues; liver; pancreas and biliary tract; endocrine; urinary; male and female genital; nervous
system; musculoskeletal; and integument.

Popular Content

 Acute Inflammation/Wound Healing and Repair I

Syllabus
Objectives

 After completing Part I, the dental student should be able to demonstrate a knowledge of the terminology of
pathology as well as understand the processes of cellular tissues injury, environmental pathologies,
developmental disorders, inflammation and repair mechanisms, neoplastic disturbances and tumors, and fluid
and hemodynamic disorders.
  After completing Part II, the dental student should be able to know the types and specific features of diseases
covered in the course that can affect the cardiovascular system, respiratory system, nose, pharnyx, larnyx and
esophagus, gastrointestinal system, hepatic and biliary tract (including hepatitis and diabetes mellitus), nervous
system, urinary system, gynecological and obstetrics, breast disease, male genital system, and musculoskeletal
and integument.

1. Definitions

1.1. Pathology:

The study of disease; deals with the etiology, pathogenesis, physiology, and structural and functional alterations that
result from disease.

1.2. General Pathology:

The study of basic pathologic processes that underlie all diseases, such as cellular pathology, inflammation and repair,
fluid and hemodynamic derangements, neoplasias, and also the study of genetic, immunologic, metabolic and deficiency,
infections, environmental, pediatric and geriatric diseases.

1.3. Systemic Pathology:

The study of diseases affecting specific organs and their systems such as cardiovascular, blood, hematopoietic and
lymphoreticular, respiratory, gastrointestinal, hepatobiliary, genitourinary, pancreas, male reproductive, breast and
female reproductive, endocrine, musculoskeletal, neural and specialized neural, and skin.

2. Readings and Educational Material

2.1. Course Syllabus

The syllabus contains the basic information about the course including goals, general and specific objectives, lecture
schedule, examination information, grading policies, departmental rules and guidelines, course directors' contact
information, etc. The student is urged to refer to this document on a regular basis.

2.2. Textbooks

2.2.1. Required:

 Pathology: Illustrated Review in Color, 2nd edition, by A. Stevens and J. Lowe, Mosby, 2000.
This softcover textbook has excellent course summaries and is generously illustrated. Key points are clearly
outlined. Each chapter has specific questions with an answer key provided. The depth of this book is ideal for
this course and is the primary reference for Basic Human Pathology, Part 1 lecture content and forms the
organizational structure and content for Basic Human Pathology, Part II course.

2.2.2. Recommended:

 Dorland's Illustrated Medical Dictionary, Saunders, 2005 or Stedman's Medical Dictionary, Lippincott Williams and
Wilkins, 2005.
A medical dictionary will be an invaluable aid for this course, oral pathology and the medicine courses. It is
highly recommended that you purchase one and have it readily available during your reading of the Basic Human
Pathology courses' notes and assigned textbook readings.
 Schneider AS and Szanto PA. Board Review Series: Pathology, 3rd edition, Lippincott Williams and Wilkins, 2006.
ISBN# 0-7817-6022-4.
 This softcover textbook is an excellent review and is formatted in outline note form. It also contains questions
at the end of each chapter along with answers and explanations. It is also an excellent aid for preparation for
the National Board Dental Examination, part one. It is a supplemental reference for the Basic Human Pathology
courses.
 Robbins Basic Pathology, 7th edition, by V. Kumar, R. Cotran and S. Robbins, Saunders, 2003.
 Rubin's Pathology: Clinicopathologic Foundations of Medicine, 4th edition, by E. Rubin, et al., Lippincott,
Williams and Wilkins, 2005.

2.2.3. Reference

 Kumar V, Cotran R, Robbins T. Robbins Basic Pathology, 7th Edition, Saunders, 2003.
This hardcover textbook is acknowledged as "the small bible" in the field of pathology, particularly for medical
school training. In many areas, its detail is beyond the scope of this course. Its numerous illustrations would,
however, be of significant value for the Basic Human Pathology courses.
 Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease, 7th edition, Saunders, 2005.
This hardcover textbook is acknowledged as "the small bible" in the field of pathology, particularly for medical
school training. In many areas, its detail is beyond the scope of this course. Its numerous illustrations would,
however, be of significant value for the Basic Human Pathology courses.
 Rubin E, et al. Essential Pathology, 3rd edition, Lippincott, Williams and Wilkins, 2001.
This is the chief publishing rival to the 2003 Robbins Basic Pathology textbook (see above) and is a paperback,
condensed version of Rubin E, et al. Rubin's Pathology: Clinicopathologic Foundations of Medicine, 5th edition,
Lippincott, Williams and Wilkins, 2007. Its illustrations would be of significant supplemental value for the Basic
Human Pathology courses.

3. Evaluating Student Knowledge and Performance

Examination guidelines and policies for this course are implemented as outlined in the current TUSDM's Student Handbook
and Curriculum Procedures Manual.

3.1. Interim Examinations/Final Examination and Weighting:

 Interim examination #1 = 30% of course grade

3.2. Examples of Question Formats for Examinations

BEST ANSWER FORMAT:

Which of the following is an abnormal development of the bony arch of the spinal column while the meninges and spinal
cord are normal?

1. encephalocele
2. leukodystrophy
3. menigocele
4. spina bifida occulta
5. myelocele

NEGATIVE STEM FORMAT:

Each of the following is a developmental abnormality of the spinal cord EXCEPT one. Which one is the exception?

1. encephlocele
2. myelocele
3. meningocele
4. meningomyelocele.

Calendar
Sessio Type Title
n

1 Lecture Course Introduction & Cellular Adaptations to Disease/Cell Injury and Death I (General)

2 Lecture Cellular Adaptations to Disease/Cell Injury and Death II (General)

3 Lecture Developmental and Genetic Factors in Disease (General)

4 Lecture Environmental Factors in Disease (General)

5 Lecture Acute Inflammation/Wound Healing and Repair I (General)

6 Examinatio Examination (General)

7 Lecture Acute Inflammation/Wound Healing and Repair II (General)

8 Lecture Chronic Inflammation (General)

9 Lecture Neoplasia (General)

10 Lecture Vascular Hemodynamics (General)

11 Examinatio Final Examination, Part I (General)

12 Lecture Cardiovascular System I (Systemic)

13 Lecture Cardiovascular System II (Systemic)

14 Lecture Respiratory System I (Systemic)

15 Lecture Respiratory System II (Systemic)

16 Lecture Hepatobiliary I (Sytemic)

17 Examinatio Examination (Systemic)

18 Lecture Hepatobiliary II - Biliary Tract and Pancreas (Systemic)

19 Lecture Sinonasal and Upper Aerodigestive Tract - Ear, Nose, Throat, Larynx, Esophagus (Systemic)

20 Lecture Gastrointestinal I - Stomach, Small and Large Intestine (Systemic)

21 Lecture Gastrointestinal II - Small and Large Intestine, cont'd. (Systemic)

22 Lecture Nervous System I - Trauma, Infection, Demyelinating Diseases (Systemic)

23 Lecture Nervous System II - Demyelinating and Degenerative Diseases, Metabolic and Tumors
(Systemic)

24 Lecture Genitourinary I - Urinary System (Systemic)

25 Examinatio Examination (Systemic)

26 Lecture Genitourinary II - Urinary System (Systemic)

27 Lecture Genitourinary III - Obstetric-Gynecology (Systemic)

28 Lecture Genitourinary IV - Breast Disease and Male Genital System (Systemic)

29 Lecture Musculoskeletal System and Integument (Systemic)