Pharmaceutics I
Lectures
By
Abhimanyu Dev, PhD
Assistant Professor
Department of Pharmaceutical sciences & Technology
Birla Institute of Technology Mesra
Ranchi
Numerical Problems
1. Using Young’s formula calculate the dose of a drug for 6-year-old child if adult dose is 240 mg.
Given that,
Age of child = 6 years
Adult dose = 240 mg
Using Young’s formula
Dose of child = 𝑥 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒(𝑚𝑔)
= X 240 = 80 mg
Numerical Problems
2. What is the dose of a drug for a 9 months old child if an average adult dose is 25 mg?
Given,
Adult dose = 25 mg
Using Fried’s formula,
Dose for infant = 𝑋 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒 (𝑚𝑔)
𝑥 25 = 1.5 𝑚𝑔
3. The adult dose of a drug is 600mg. What is the dose of the same for a 2 year old child?
Given,
Adult dose = 600 mg
For a 2 years old child (Dilling’s formula)
Dose = X Adult dose
2
𝑥 600 = 60 𝑚𝑔
20
Hence, dose of the drug for a 2 year old child is 60 mg
Numerical Problems
4. What is the dose of a drug for a child that weighs 66 pounds, if the dose is stated as 2.5mg/kg body
weight?
Given,
Weight of child = 66 pounds
Stated dose = 2.5 mg/kg
We know that 1 pound = 0.454 kg
So, 66 pounds = 0.454 X 66 = 29.96 kg
Hence, the dose required is calculated as,
According to the question, 2.5 mg drug is required for 1 kg body weight
2.5 mg 1 kg
? = 29.96 kg
29.96 X 2.5
= 74.9 mg
Hence the dose is 74.9 mg = 75 mg
Numerical Problems
5. Calculate the dose for a 5 year old boy, 12 months baby, 43 kg patient to a paracetamol (Adult dose is
500 mg).
Given,
Adult dose = 500mg
For 5 year old boy
Using Dilling’s formula
Dose = X Adult dose
𝑥500 = 125 𝑚𝑔
Paracetamol dose for 5 year old boy is 125 mg.
For 12 months baby
Using fried’s formula,
Dose for infant Age = 𝑋 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒 (𝑚𝑔)
12
𝑥500 = 40 𝑚𝑔
150
Paracetamol dose for 12 months baby is 40 mg
For 43 kg patient
Using Clark’s formula
Dose for child = 𝑥 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒
X 500 = 307.14 mg
Numerical Problems
6. The usual initial dose of chlorambucil is 150 μg/kg body weight once a day. How many milligrams should be
administered to a person weighing 154 lb?
1 pound (1lb) = 0.4536 kg
154 lb. = 0.4536 x 154 = 69.85 kg
Body weight of a person = 69.85 kg
Dose of chlorambucil = 150 μg/kg
For 1 kg, body weight dose = 0.150 mg
For 69.85 kg, body weight dose = 0.150 X 69.85 = 10.4 mg
Hence, chlorambucil dose for a person weighing 154 lb is 10.4mg.
7. 25 mg of ephedrine hydrochloride can be given to an adult. What will be the dose for nine months old infant
and a boy of 16 years?
Given,
Adult dose of ephedrine hydrochloride = 25 mg
9 months old infant dose = 𝑋 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒 (𝑚𝑔)
9
𝑥 25 = 1.5 𝑚𝑔
150
Hence, ephedrine hydrochloride dose for 9 months old infant is 1.5 mg.
16 years old dose = 𝑥 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒(𝑚𝑔)
16
𝑥 25 = 14.29 𝑚𝑔
16 + 12
Numerical Problems
8. The adult dose of a drug is 200 mg. what is the dose for a one-year old child.
Given,
Adult dose = 200 mg
Dose for 1-year old child =?
Using Dilling’s formula
Dose = X Adult dose (mg)
X 200 = 10 mg
9. Calculate the dose of a drug for 4 year old child if the adult dose of the drug is 120 mg using Young’s
formula
Given,
Age of child = 4 year
Adult dose = 120 mg
Using Young’s formula
Dose of child = 𝑥 𝐴𝑑𝑢𝑙𝑡 𝑑𝑜𝑠𝑒(𝑚𝑔)
4
𝑥 120 = 30 𝑚𝑔
4 + 12
Hence, the required child dose is 30 mg
