GeneMANIA report

Created on : 27 May 2025 19:18:41

Last database update : 13 August 2021 00:00:00
Application version : 3.6.0

Networks Functions
Physical Interactions N/A

Co-expression

Predicted

Co-localization

Genetic Interactions

Pathway

Shared protein domains

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Search parameters
Organism Homo sapiens (human)
Genes CRX
Network Automatically selected weighting method
weighting
Networks A

Abbasi-Schild-Poulter-2019 , Abu-Odeh-Aqeilan-2014 , Achuthankutty-Mailand-

2019 , Agrawal-Sedivy-2010 , Ahn-Lee-2008 , Albers-Koegl-2005 , Alexander-Wang-
2018 , Alexandru-Deshaies-2008 , Alizadeh-Staudt-2000 , Alsulami-Cagney-2019 ,
An-Sun-2017 , Andresen-Flores-Morales-2014 , Arbogast-Gros-2019 , Arijs-
Rutgeerts-2009 , Arroyo-Aloy-2014 , Arroyo-Aloy-2015 , Asadi-Dhanvantari-2018
B
Bailey-Hieter-2015 , Bandyopadhyay-Ideker-2010 , Banks-Washburn-2016 ,
Bantscheff-Drewes-2011 , Barr-Knapp-2009 , Barreiro-Alonso-Cerdán-2018 , Barrios-
Rodiles-Wrana-2005 , Behrends-Harper-2010 , Behzadnia-Lührmann-2007 ,
Benleulmi-Chaachoua-Jockers-2016 A , Benleulmi-Chaachoua-Jockers-2016 B ,
Bennett-Harper-2010 , Benzinger-Hermeking-2005 , Berggård-James-2006 , Bett-
Hay-2013 , Beyer-Boldt-2018 , Bhatnagar-Attie-2014 , Bild-Nevins-2006 B ,
BIOGRID-SMALL-SCALE-STUDIES , BIOGRID-SMALL-SCALE-STUDIES ,
Bishof-Seyfried-2018 , Blandin-Richard-2013 , Blomen-Brummelkamp-2015 ,
Blomen-Brummelkamp-2015 , Bogachek-Weigel-2014 , Boldrick-Relman-2002 ,
Boldt-Roepman-2016 , Botham-Schimmer-2019 , Bouwmeester-Superti-Furga-2004 ,
Brady-Omary-2018 , Brajenovic-Drewes-2004 , Brehme-Superti-Furga-2009 ,
Burington-Shaughnessy-2008 , Butland-Hayden-2014 , Byron-Humphries-2012
C
Cai-Conaway-2007 , Camargo-Brandon-2007 , Campos-Reinberg-2015 , Cao-
Chinnaiyan-2014 , Carmon-Liu-2014 , Caron-van Attikum-2019 , CELL_MAP ,
Chen-Brown-2002 , Chen-Ge-2013 A , Chen-Ge-2013 B , Chen-Guan-2018 , Chen-
Huang-2014 , Chen-Krogan-2018 , Chen-Yu-2018 , Chen-Zhang-2013 , Chen-Zhou-
2019 , Cheng-DeCaprio-2017 , Chi-Reed-2018 , Chitale-Richly-2017 , Choi-Beutler-
2019 , Choi-Busino-2018 , Choudhury-Michlewski-2017 , Christianson-Kopito-2011 ,
Cloutier-Coulombe-2013 , Cloutier-Coulombe-2017 , Colicelli-2010 , Colland-
Gauthier-2004 , Conte-Perez-Oliva-2018 , Cooper-Green-2015 , Corominas-
Iakoucheva-2014 , Couzens-Gingras-2013 , Cox-Rizzino-2013 , Coyaud-Raught-
2015 , Crow-Cristea-2017
D
Daakour-Twizere-2016 , Dabbaghizadeh-Tanguay-2018 , Dart-Wells-2015 , Das-
Broemer-2019 , Davis-Glaunsinger-2015 , de Hoog-Mann-2004 , Devarajan-Ketha-
Kumar-2012 , Diner-Cristea-2015 , Dittmer-Misteli-2014 , Dobbin-Giordano-2005 ,

2 of 41
D

Douanne-Bidère-2019 , Drissi-Boisvert-2015 , Du-Krogan-2017

E
Elliott-Gyrd-Hansen-2016 , Emdal-Olsen-2015 , Enzo-Dupont-2015 , Ertych-
Bastians-2016 , Ewing-Figeys-2007
F
Fang-Lin-2011 , Faust-Frankel-2018 , Fenner-Prehn-2010 , Floyd-Pagliarini-2016 ,
Foerster-Ritter-2013 , Fogeron-Lange-2013 , Fonseca-Damgaard-2015 , Foster-
Marshall-2013 , Fragoza-Yu-2019 , Freibaum-Taylor-2010
G
Gabriel-Baumgrass-2016 , Gallardo-Vara-Bernabeu-2019 , Galligan-Howley-2015 ,
Gao-Reinberg-2012 , Gao-Vaziri-2016 , Garzia-Sonenberg-2017 , Gautier-Hall-2009 ,
Giannone-Liu-2010 , Gilmore-Washburn-2016 , Giurato-Tarallo-2018 , Glatter-
Gstaiger-2009 , Gloeckner-Ueffing-2007 , Goehler-Wanker-2004 , Gordon-Krogan-
2020 , Goudreault-Gingras-2009 , Greco-Cristea-2011 , Grossmann-Stelzl-2015 ,
Guarani-Harper-2014 , Guard-Old-2019 , Guardia-Laguarta-Przedborski-2019 ,
Guderian-Grimmler-2011 , Gupta-Pelletier-2015
H
Han-Bassik-2017 A , Han-Bassik-2017 B , Hanson-Clayton-2014 , Hauri-Beisel-2016 ,
Hauri-Gstaiger-2013 , Havrylov-Redowicz-2009 , Havugimana-Emili-2012 , Hayes-
Urbé-2012 , Hegele-Stelzl-2012 A , Hegele-Stelzl-2012 B , Heidelberger-Beli-2018 ,
Hein-Mann-2015 , Hermjakob-Apweiler-2004 , Herr-Helleday-2015 , Hoffmeister-
Längst-2017 , Horlbeck-Gilbert-2018 A , Horlbeck-Gilbert-2018 B , Hosp-Selbach-
2015 , Hou-Chen-2018 , Hou-Huang-2017 , Hu-Woods-2019 , Hu-Yin-2019 , Hubel-
Pichlmair-2019 , Huber-Hoelz-2017 , HUMANCYC , Humphries-Humphries-2009 ,
Hussain-Aldaz-2018 , Hutchins-Peters-2010 , Huttlin-Gygi-2015 , Huttlin-Harper-
2017 , Hüttenhain-Krogan-2019
I
I2D-BIND-Fly2Human , I2D-BIND-Mouse2Human , I2D-BIND-Rat2Human , I2D-
BIND-Worm2Human , I2D-BIND-Yeast2Human , I2D-BioGRID-Fly2Human , I2D-
BioGRID-Mouse2Human , I2D-BioGRID-Rat2Human , I2D-BioGRID-
Worm2Human , I2D-BioGRID-Yeast2Human , I2D-Chen-Pawson-2009-PiwiScreen-
Mouse2Human , I2D-Formstecher-Daviet-2005-Embryo-Fly2Human , I2D-
Formstecher-Daviet-2005-Head-Fly2Human , I2D-Giot-Rothbert-2003-High-
Fly2Human , I2D-Giot-Rothbert-2003-Low-Fly2Human , I2D-INNATEDB-
Mouse2Human , I2D-IntAct-Fly2Human , I2D-IntAct-Mouse2Human , I2D-IntAct-
Rat2Human , I2D-IntAct-Worm2Human , I2D-IntAct-Yeast2Human , I2D-Krogan-
Greenblatt-2006-Core-Yeast2Human , I2D-Krogan-Greenblatt-2006-NonCore-
Yeast2Human , I2D-Li-Vidal-2004-CE-DATA-Worm2Human , I2D-Li-Vidal-2004-
CORE-1-Worm2Human , I2D-Li-Vidal-2004-CORE-2-Worm2Human , I2D-Li-Vidal-
2004-interolog-Worm2Human , I2D-Li-Vidal-2004-literature-Worm2Human , I2D-Li-
3 of 41
I

Vidal-2004-non-core-Worm2Human , I2D-Manual-Mouse2Human , I2D-Manual-

Rat2Human , I2D-MGI-Mouse2Human , I2D-MINT-Fly2Human , I2D-MINT-
Mouse2Human , I2D-MINT-Rat2Human , I2D-MINT-Worm2Human , I2D-MINT-
Yeast2Human , I2D-MIPS-Yeast2Human , I2D-Ptacek-Snyder-2005-Yeast2Human ,
I2D-Stanyon-Finley-2004-CellCycle-Fly2Human , I2D-Tarassov-PCA-
Yeast2Human , I2D-Tewari-Vidal-2004-TGFb-Worm2Human , I2D-vonMering-
Bork-2002-High-Yeast2Human , I2D-vonMering-Bork-2002-Low-Yeast2Human ,
I2D-vonMering-Bork-2002-Medium-Yeast2Human , I2D-Wang-Orkin-2006-EScmplx-
Mouse2Human , I2D-Wang-Orkin-2006-EScmplxIP-Mouse2Human , I2D-Wang-
Orkin-2006-EScmplxlow-Mouse2Human , I2D-Yu-Vidal-2008-GoldStd-
Yeast2Human , IMID , Ingham-Pawson-2005 , Innocenti-Brown-2011 ,
INTERPRO , Iradi-Borchelt-2018 , IREF-bhf-ucl , IREF-bind , IREF-bind-
translation , IREF-biogrid , IREF-corum , IREF-dip , IREF-hpidb , IREF-hprd ,
IREF-huri , IREF-innatedb , IREF-intact , IREF-intcomplex , IREF-matrixdb ,
IREF-mbinfo , IREF-mint , IREF-mppi , IREF-quickgo , IREF-reactome , IREF-
SMALL-SCALE-STUDIES , IREF-SMALL-SCALE-STUDIES , IREF-spike , IREF-
uniprotpp , IREF-virushost , Ivanochko-Arrowsmith-2019
J
Jain-Parker-2016 , Jang-Trono-2018 , Jeronimo-Coulombe-2007 , Jiang-de Kok-
2017 , Jin-Pawson-2004 , Jirawatnotai-Sicinski-2011 , Johnson-Kerner-Wichterle-
2015 , Johnson-Shoemaker-2003 , Jones-MacBeath-2006 , Joshi-Cristea-2013 ,
Jozwik-Carroll-2016 , Jäger-Krogan-2011
K
Kahle-Zoghbi-2011 , Kaltenbach-Hughes-2007 , Kang-Shin-2015 , Karras-Soengas-
2019 , Kato-Sternberg-2014 , Katsogiannou-Rocchi-2014 , Kawahara-Paes Leme-
2017 , Keller-Lee-2014 , Kennedy-Kolch-2020 A , Kennedy-Kolch-2020 B , Khanna-
Parnaik-2018 , Kim-Major-2015 , Kneissl-Grummt-2003 , Koch-Hermeking-2007 ,
Kotlyar-Jurisica-2015 , Kristensen-Foster-2012 , Kumar-Maddika-2017 , Kumar-
Vertegaal-2017 , Kupka-Walczak-2016 , Kärblane-Sarmiento-2015 , Kırlı-Görlich-
2015
L
Lambert-Gingras-2015 , Lampert-Peter-2018 , Lau-Ronai-2012 , Lee-Choi-2016 ,
Lee-Choi-2017 , Lee-Jeong-2017 , Lee-Jou-2019 , Lee-Mayr-2019 , Lee-Songyang-
2011 , Lehner-Sanderson-2004 A , Lehner-Sanderson-2004 B , Leung-Jones-2014 ,
Leung-Miller-2017 , Li-Chen-2015 , Li-Dorf-2011 A , Li-Dorf-2011 B , Li-Dorf-2014 ,
Li-Fu-2017 , Li-Haura-2013 , Li-Hung-2019 , Li-Lu-2018 , Li-Wang-2016 , Li-Zhou-
2017 , Liebelt-Vertegaal-2020 , Lim-Zoghbi-2006 , Lin-Smith-2010 , Lipp-Guthrie-
2015 , Liu-Chen-2019 , Liu-Sun-2019 , Liu-Takahashi-2017 , Liu-Tan-2018 , Liu-
Varjosalo-2018 , Liu-Wang-2012 , Liu-Xu-2018 , Liu-Yang-2019 , Llères-Lamond-
2010 , Loch-Strickler-2012 , Low-Heck-2014 , Lu-Bohr-2017 , Lu-Zhang-2013 , Luck-
Calderwood-2020 , Lum-Cristea-2018 , Luo-Elledge-2009

4 of 41
M
Mak-Moffat-2010 , Malinová-Verheggen-2017 , Mallon-McKay-2013 , Malovannaya-
Qin-2010 , Malty-Babu-2017 , Markson-Sanderson-2009 , Martin-Elledge-2017 ,
Maréchal-Zou-2014 , Matsumoto-Nakayama-2005 , Matsuoka-Elledge-2007 ,
McCracken-Blencowe-2005 , McFarland-Nussbaum-2008 , McNamara-D'Orso-2016 ,
Meek-Piwnica-Worms-2004 , Menon-Litovchick-2019 , Milev-Mouland-2012 ,
Miyamoto-Sato-Yanagawa-2010 , Mohammed-Carroll-2013 , Moon-Kim-2014 ,
Moutaoufik-Babu-2019 , Mugabo-Lim-2018 , Muller-Demeret-2012 , Murakawa-
Landthaler-2015
N
Nakamura-Groth-2019 , Nakayama-Ohara-2002 , Napolitano-Meroni-2011 ,
Narayan-Bennett-2012 , Nassa-Weisz-2019 , Nathan-Goldberg-2013 ,
NCI_NATURE , Neganova-Lako-2011 , Newman-Keating-2003 , Noguchi-
Kawahara-2018 , Nowak-Sommer-2019
O
Oliviero-Cagney-2015 , Oliviero-Cagney-2016 , Olma-Pintard-2009 , Oláh-Ovádi-
2011 , Ouyang-Gill-2009
P
Panigrahi-Pati-2012 , Pankow-Yates-2015 , Pao-Virdee-2018 , Papp-Lamia-2015 ,
Pech-Settleman-2019 , Perez-Hernandez-Yáñez-Mó-2013 , Perez-Perri-Espinosa-
2016 , Perou-Botstein-1999 , Perou-Botstein-2000 , Persaud-Rotin-2009 A , Persaud-
Rotin-2009 B , Petschnigg-Stagljar-2014 , PFAM , Phillips-Corn-2013 , Pichlmair-
Superti-Furga-2011 , Pichlmair-Superti-Furga-2012 , Pilling-Cooper-2017 ,
Pladevall-Morera-Lopez-Contreras-2019 , Ptushkina-Ray-2017
R
Raisner-Gascoigne-2018 , Ramachandran-LaBaer-2004 , Raman-Harper-2015 ,
Ramaswamy-Golub-2001 , Ravasi-Hayashizaki-2010 , REACTOME , Reinke-
Keating-2010 , Reinke-Keating-2013 , Rengasamy-Walsh-2017 , Reyniers-Taymans-
2014 , Richter-Chrzanowska-Lightowlers-2010 , Rieger-Chu-2004 , Rivera-Paes
Leme-2018 , Rodriguez-von Kriegsheim-2016 , Roewenstrunk-de la Luna-2019 ,
Rolland-Vidal-2014 , Rosenbluh-Hahn-2016 , Rosenwald-Staudt-2001 , Ross-Perou-
2001 , Roth-Zlotnik-2006 , Rowbotham-Mermoud-2011 , Roy-Pardo-2014 , Roy-
Parent-2013 , Rual-Vidal-2005
S
Saez-Vilchez-2018 , Sahni-Vidal-2015 , Saito-Kobarg-2017 , Sala-Ampe-2017 ,
Salvetti-Greco-2016 , Sang-Jackson-2011 , Sato-Conaway-2004 , Savidis-Brass-2016 ,
Schadt-Shoemaker-2004 , Schiza-Diamandis-2018 , Scholz-Taylor-2016 , Scifo-
Lalowski-2015 , Scott-Guy-2017 , Scott-Schulman-2016 , Shami Shah-Baskin-2019 ,
Shen-Chen-2019 , Shen-Mali-2017 , Sherman-Teitell-2010 , Simabuco-Zanchin-2019 ,
Singh-Moore-2012 , So-Colwill-2015 , Sokolina-Stagljar-2017 , Soler-López-Aloy-
2011 , Sowa-Harper-2009 , Srivas-Ideker-2016 , St-Denis-Gingras-2015 , St-Denis-
5 of 41
S

Gingras-2016 , Stehling-Lill-2012 , Stehling-Lill-2013 , Stelzl-Wanker-2005 , Stuart-

Kim-2003 , Sundell-Ivarsson-2018 , Suter-Wanker-2013 , Swayampakula-Dedhar-
2017
T
Taipale-Lindquist-2012 , Taipale-Lindquist-2014 , Takahashi-Conaway-2011 , Tang-
Wang-2019 , Tarallo-Weisz-2011 , Teixeira-Gomes-2010 , Teixeira-Laman-2016 A ,
Teixeira-Laman-2016 B , Thalappilly-Dusetti-2008 , Thompson-Luchansky-2014 ,
Tiemann-Kani-2019 , Tomkins-Manzoni-2018 , Tong-Moran-2014 , Toyoshima-
Grandori-2012 , Trepte-Wanker-2018 A , Trepte-Wanker-2018 B , Tsai-Cristea-2012
U
Ugidos-Vandenbroeck-2019
V
Van Acker-Dewilde-2019 , Van Alstyne-Pellizzoni-2018 , Van Quickelberghe-
Gevaert-2018 , van Wijk-Timmers-2009 , Vandamme-Angrand-2011 , Varier-
Vermeulen-2016 , Varjosalo-Gstaiger-2013 A , Varjosalo-Gstaiger-2013 B ,
Varjosalo-Superti-Furga-2013 , Vastrik-Stein-2007 , Venkatesan-Vidal-2009 , Viita-
Vartiainen-2019 , Vinayagam-Wanker-2011 , Virok-Fülöp-2011 , Vizeacoumar-
Moffat-2013 , von Hundelshausen-Weber-2017
W
Wallach-Kramer-2013 , Wan-Emili-2015 , Wang-Balch-2006 , Wang-Cheung-2015 ,
Wang-He-2008 , Wang-Huang-2017 , Wang-Liu-2019 , Wang-Maris-2006 , Wang-
Xiong-2019 , Wang-Xu-2015 , Wang-Yang-2011 , Watanabe-Fujita-2018 , Weimann-
Stelzl-2013 A , Weimann-Stelzl-2013 B , Weinmann-Meister-2009 , Weishäupl-
Schmidt-2019 , Weith-Meyer-2018 , Whisenant-Salomon-2015 , Wilkinson-Coba-
2019 , Willingham-Muchowski-2003 , Winczura-Jensen-2018 , Wong-O'Bryan-2012 ,
Woods-Monteiro-2012 A , Woods-Monteiro-2012 B , Woodsmith-Sanderson-2012 ,
Wu-Garvey-2007 , Wu-Li-2007 , Wu-Ma-2012 , Wu-Stein-2010 , Wu-Stein-2010
X
Xiao-Brown-2018 , Xiao-Lefkowitz-2007 , Xie-Cong-2013 , Xie-Green-2012 , Xie-
Zhang-2017 , Xu-Ye-2012 , Xu-Zetter-2016
Y
Yachie-Roth-2016 , Yadav-Varjosalo-2017 , Yamauchi-Maeda-2018 , Yang-Brasier-
2015 , Yang-Chen-2010 , Yang-Maurer-2018 , Yang-Vidal-2016 , Yang-Wang-2018 ,
Yao-Stagljar-2017 A , Yao-Stagljar-2017 B , Yatim-Benkirane-2012 , Yeung-
Dougan-2019 , Yu-Chow-2013 , Yu-Engel-2018 , Yu-Vidal-2011 , Yue-Liu-2018
Z
Zanon-Pichler-2013 , Zeller-Wei-2006 , Zhang-Shang-2006 , Zhang-Vermeulen-2017 ,
Zhang-Wang-2018 , Zhang-Wheeler-2014 , Zhang-Xu-2018 , Zhang-Zou-2011 , Zhao-
Krug-2005 , Zhao-Yang-2011 , Zhong-Vidal-2016 , Zhou-Conrads-2004 , Zhou-
6 of 41
Z

Hanemann-2016 , Zhu-Liu-2018

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Genes
Gene Description Rank
CRX cone-rod homeobox [Source:HGNC Symbol;Acc:HGNC:2383] N/A
NRL neural retina leucine zipper [Source:HGNC Symbol;Acc:HGNC:8002] 1
ATXN7 ataxin 7 [Source:HGNC Symbol;Acc:HGNC:10560] 2
NR2E3 nuclear receptor subfamily 2 group E member 3 [Source:HGNC Symbol;Acc: 3
HGNC:7974]
RAX2 retina and anterior neural fold homeobox 2 [Source:HGNC Symbol;Acc: 4
HGNC:18286]
PDC phosducin [Source:HGNC Symbol;Acc:HGNC:8759] 5

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Networks
Physical Interactions 77.64%

Wang-Huang-2017 4.41%
Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Wang et al (2017). Mol Cell
Proteomics
Physical Interactions with 73 interactions from BioGRID

von Hundelshausen-Weber-2017 2.33%

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. von Hundelshausen et al
(2017). Sci Transl Med
Physical Interactions with 213 interactions from iRefIndex

McFarland-Nussbaum-2008 2.21%
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland et al (2008). Mol Cell
Proteomics
Physical Interactions with 159 interactions from BioGRID

Guardia-Laguarta-Przedborski-2019 1.66%
PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. Guardia-Laguarta et al (2019). J Neurosci
Physical Interactions with 468 interactions from BioGRID

Maréchal-Zou-2014 1.46%
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Maréchal et al (2014). Mol Cell
Physical Interactions with 996 interactions from BioGRID

Singh-Moore-2012 1.40%
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Singh et al (2012). Cell
Physical Interactions with 235 interactions from iRefIndex

Whisenant-Salomon-2015 1.39%
The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene
Expression in Human CD4 T Cells. Whisenant et al (2015). PLoS One
Physical Interactions with 237 interactions from BioGRID

Tsai-Cristea-2012 1.30%
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in
regulation of RNA polymerase I transcription. Tsai et al (2012). Mol Cell Proteomics
Physical Interactions with 651 interactions from BioGRID

Kneissl-Grummt-2003 1.26%
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl et al (2003). J Mol Biol
Physical Interactions with 81 interactions from BioGRID

Zhang-Vermeulen-2017 1.20%
An Interaction Landscape of Ubiquitin Signaling. Zhang et al (2017). Mol Cell
Physical Interactions with 242 interactions from BioGRID

Narayan-Bennett-2012 1.16%
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic

9 of 41
Physical Interactions 77.64%
Narayan-Bennett-2012
pathways. Narayan et al (2012). PLoS One
Physical Interactions with 109 interactions from BioGRID

Li-Fu-2017 1.13%
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Li et
al (2017). Nat Commun
Physical Interactions with 749 interactions from BioGRID

Li-Hung-2019 1.09%
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Li et al (2019). Gastroenterology
Physical Interactions with 179 interactions from BioGRID

Richter-Chrzanowska-Lightowlers-2010 1.07%
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Richter et al (2010).
EMBO J
Physical Interactions with 204 interactions from BioGRID

Ertych-Bastians-2016 1.07%
CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. Ertych
et al (2016). Proc Natl Acad Sci U S A
Physical Interactions with 486 interactions from BioGRID

Yu-Chow-2013 1.01%
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Yu
et al (2013). PLoS One
Physical Interactions with 280 interactions from BioGRID

Lee-Jou-2019 0.98%
Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in
astrocytes. Lee et al (2019). Acta Neuropathol Commun
Physical Interactions with 218 interactions from BioGRID

Colicelli-2010 0.95%
ABL tyrosine kinases: evolution of function, regulation, and specificity. Colicelli (2010). Sci Signal
Physical Interactions with 147 interactions from iRefIndex

Matsumoto-Nakayama-2005 0.94%
Large-scale analysis of the human ubiquitin-related proteome. Matsumoto et al (2005). Proteomics
Physical Interactions with 311 interactions from BioGRID

Kotlyar-Jurisica-2015 0.94%
In silico prediction of physical protein interactions and characterization of interactome orphans. Kotlyar et al (2015). Nat Methods
Physical Interactions with 121 interactions from BioGRID

Petschnigg-Stagljar-2014 0.92%
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Petschnigg et
al (2014). Nat Methods
Physical Interactions with 116 interactions from iRefIndex

Guarani-Harper-2014 0.89%
TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the

10 of 41
Physical Interactions 77.64%
Guarani-Harper-2014
MCIA complex. Guarani et al (2014). Mol Cell Biol
Physical Interactions with 323 interactions from BioGRID

Lu-Zhang-2013 0.81%
The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight
regulation maintains the metaphase to anaphase transition. Lu et al (2013). J Biol Chem
Physical Interactions with 186 interactions from iRefIndex

Berggård-James-2006 0.78%
140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård et al
(2006). J Proteome Res
Physical Interactions with 151 interactions from BioGRID

Kupka-Walczak-2016 0.75%
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Kupka et al (2016). Cell Rep
Physical Interactions with 411 interactions from BioGRID

Freibaum-Taylor-2010 0.72%
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Freibaum
et al (2010). J Proteome Res
Physical Interactions with 160 interactions from iRefIndex

Perez-Perri-Espinosa-2016 0.65%
The TIP60 Complex Is a Conserved Coactivator of HIF1A. Perez-Perri et al (2016). Cell Rep
Physical Interactions with 118 interactions from BioGRID

Jirawatnotai-Sicinski-2011 0.65%
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Jirawatnotai et al (2011).
Nature
Physical Interactions with 122 interactions from BioGRID

Kırlı-Görlich-2015 0.65%
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı et al (2015). Elife
Physical Interactions with 1,034 interactions from BioGRID

Leung-Jones-2014 0.62%
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit,
ErbB, and androgen receptor interactome. Leung et al (2014). Mol Cell Proteomics
Physical Interactions with 199 interactions from iRefIndex

Yatim-Benkirane-2012 0.60%
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Yatim et al (2012).
Mol Cell
Physical Interactions with 127 interactions from BioGRID

Mak-Moffat-2010 0.60%
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of
pluripotency. Mak et al (2010). Mol Cell Proteomics
Physical Interactions with 110 interactions from BioGRID

Chen-Ge-2013 B 0.60%

11 of 41
Physical Interactions 77.64%
Chen-Ge-2013 B
Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen et al (2013). Mol
Cell Proteomics
Physical Interactions with 173 interactions from BioGRID

Zanon-Pichler-2013 0.59%
Profiling of Parkin-binding partners using tandem affinity purification. Zanon et al (2013). PLoS One
Physical Interactions with 195 interactions from BioGRID

Raisner-Gascoigne-2018 0.57%
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Raisner et al (2018). Cell Rep
Physical Interactions with 174 interactions from BioGRID

Jang-Trono-2018 0.57%
KAP1 facilitates reinstatement of heterochromatin after DNA replication. Jang et al (2018). Nucleic Acids Res
Physical Interactions with 699 interactions from BioGRID

Ahn-Lee-2008 0.56%
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn et al (2008). Biochem
J
Physical Interactions with 105 interactions from BioGRID

IREF-reactome 0.55%
Physical Interactions with 111,926 interactions from iRefIndex

Vastrik-Stein-2007 0.55%
Reactome: a knowledge base of biologic pathways and processes. Vastrik et al (2007). Genome Biol
Physical Interactions with 111,926 interactions from iRefIndex

Liu-Varjosalo-2018 0.50%
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Liu et al (2018). Nat Commun
Physical Interactions with 825 interactions from BioGRID

Wang-Liu-2019 0.48%
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through
deubiquitinating TGF-β receptors and caveolin-1. Wang et al (2019). EBioMedicine
Physical Interactions with 180 interactions from iRefIndex

Murakawa-Landthaler-2015 0.47%
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Murakawa et al
(2015). Nat Commun
Physical Interactions with 155 interactions from BioGRID

Elliott-Gyrd-Hansen-2016 0.47%
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Elliott et al (2016). Mol Cell
Physical Interactions with 543 interactions from BioGRID

Lee-Choi-2016 0.46%
Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during
neuronal differentiation. Lee et al (2016). Sci Rep
Physical Interactions with 199 interactions from BioGRID

12 of 41
Physical Interactions 77.64%

Hüttenhain-Krogan-2019 0.46%
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain et al (2019). Cell
Host Microbe
Physical Interactions with 384 interactions from BioGRID

IREF-bhf-ucl 0.46%
Physical Interactions with 1,155 interactions from iRefIndex

Leung-Miller-2017 0.45%
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Leung et al (2017). Genes Dev
Physical Interactions with 247 interactions from BioGRID

Scifo-Lalowski-2015 0.45%
Quantitative analysis of PPT1 interactome in human neuroblastoma cells. Scifo et al (2015). Data Brief
Physical Interactions with 199 interactions from BioGRID

Koch-Hermeking-2007 0.45%
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Koch et al (2007). Cell Cycle
Physical Interactions with 207 interactions from BioGRID

Chen-Zhang-2013 0.43%
Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis. Chen et al (2013). J
Proteome Res
Physical Interactions with 182 interactions from BioGRID

Neganova-Lako-2011 0.42%
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
Neganova et al (2011). Stem Cells
Physical Interactions with 307 interactions from iRefIndex

Taipale-Lindquist-2012 0.42%
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale et al (2012). Cell
Physical Interactions with 390 interactions from iRefIndex

Heidelberger-Beli-2018 0.41%
Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. Heidelberger et al (2018).
EMBO Rep
Physical Interactions with 1,347 interactions from BioGRID

Persaud-Rotin-2009 A 0.39%
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud et al (2009). Mol
Syst Biol
Physical Interactions with 139 interactions from BioGRID

McNamara-D'Orso-2016 0.38%
KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.
McNamara et al (2016). Mol Cell
Physical Interactions with 276 interactions from BioGRID

Xie-Cong-2013 0.38%
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-
dependent self-degradation. Xie et al (2013). J Biol Chem

13 of 41
Physical Interactions 77.64%
Xie-Cong-2013
Physical Interactions with 170 interactions from BioGRID

Zhou-Conrads-2004 0.38%
"An investigation into the human serum ""interactome""." Zhou et al (2004). Electrophoresis
Physical Interactions with 112 interactions from iRefIndex

Alsulami-Cagney-2019 0.34%
SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18. Alsulami et al
(2019). Mol Cell Proteomics
Physical Interactions with 288 interactions from BioGRID

Beyer-Boldt-2018 0.34%
CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Beyer et al (2018). Mol
Cell Proteomics
Physical Interactions with 213 interactions from BioGRID

Fogeron-Lange-2013 0.34%
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Fogeron et al (2013). Nat Commun
Physical Interactions with 1,492 interactions from BioGRID

Phillips-Corn-2013 0.33%
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Phillips et al (2013). Proc
Natl Acad Sci U S A
Physical Interactions with 142 interactions from BioGRID

IREF-hpidb 0.33%
Physical Interactions with 166 interactions from iRefIndex

Diner-Cristea-2015 0.33%
Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes
Simplex Virus-1 Immunosuppression. Diner et al (2015). Mol Cell Proteomics
Physical Interactions with 334 interactions from BioGRID

Malovannaya-Qin-2010 0.32%
Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya et al (2010). Proc
Natl Acad Sci U S A
Physical Interactions with 299 interactions from BioGRID

Barr-Knapp-2009 0.32%
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr et al (2009). Cell
Physical Interactions with 173 interactions from iRefIndex

Faust-Frankel-2018 0.32%
The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Faust et al (2018).
Elife
Physical Interactions with 2,200 interactions from BioGRID

Pladevall-Morera-Lopez-Contreras-2019 0.32%
Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS
stability. Pladevall-Morera et al (2019). Nucleic Acids Res
Physical Interactions with 621 interactions from BioGRID

14 of 41
Physical Interactions 77.64%

Fenner-Prehn-2010 0.30%
Expanding the substantial interactome of NEMO using protein microarrays. Fenner et al (2010). PLoS One
Physical Interactions with 103 interactions from iRefIndex

Keller-Lee-2014 0.29%
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Keller et al
(2014). Mol Cell
Physical Interactions with 147 interactions from iRefIndex

Persaud-Rotin-2009 B 0.29%
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud et al (2009). Mol
Syst Biol
Physical Interactions with 155 interactions from BioGRID

Oliviero-Cagney-2016 0.29%
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Oliviero et al
(2016). Mol Cell Proteomics
Physical Interactions with 638 interactions from BioGRID

Nassa-Weisz-2019 0.29%
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. Nassa et al (2019). Sci
Data
Physical Interactions with 1,490 interactions from BioGRID

Weinmann-Meister-2009 0.28%
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Weinmann et al (2009). Cell
Physical Interactions with 96 interactions from BioGRID

Yang-Brasier-2015 0.28%
Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing
Mediated by the DEAD Box (DDX)-5/17 RNA Helicases. Yang et al (2015). Mol Cell Proteomics
Physical Interactions with 195 interactions from iRefIndex

Kristensen-Foster-2012 0.28%
A high-throughput approach for measuring temporal changes in the interactome. Kristensen et al (2012). Nat Methods
Physical Interactions with 7,044 interactions from BioGRID

Behzadnia-Lührmann-2007 0.27%
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia et al
(2007). EMBO J
Physical Interactions with 107 interactions from iRefIndex

Llères-Lamond-2010 0.26%
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. Llères et al (2010).
EMBO Rep
Physical Interactions with 848 interactions from BioGRID

Weishäupl-Schmidt-2019 0.26%
Physiological and pathophysiological characteristics of ataxin-3 isoforms. Weishäupl et al (2019). J Biol Chem
Physical Interactions with 202 interactions from iRefIndex

Varjosalo-Gstaiger-2013 B 0.25%

15 of 41
Physical Interactions 77.64%
Varjosalo-Gstaiger-2013 B
The protein interaction landscape of the human CMGC kinase group. Varjosalo et al (2013). Cell Rep
Physical Interactions with 308 interactions from BioGRID

Hein-Mann-2015 0.24%
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein et al (2015). Cell
Physical Interactions with 27,015 interactions from BioGRID

Hosp-Selbach-2015 0.24%
Quantitative interaction proteomics of neurodegenerative disease proteins. Hosp et al (2015). Cell Rep
Physical Interactions with 365 interactions from BioGRID

Hutchins-Peters-2010 0.24%
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al (2010). Science
Physical Interactions with 1,783 interactions from BioGRID

Greco-Cristea-2011 0.24%
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Greco et al (2011). Mol Cell
Proteomics
Physical Interactions with 256 interactions from BioGRID

Thompson-Luchansky-2014 0.24%
Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA
damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Thompson et al (2014). J Biol Chem
Physical Interactions with 244 interactions from iRefIndex

Xiao-Lefkowitz-2007 0.24%
Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Xiao et al (2007). Proc Natl Acad Sci U S
A
Physical Interactions with 404 interactions from BioGRID

Gloeckner-Ueffing-2007 0.23%
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Gloeckner
et al (2007). Proteomics
Physical Interactions with 100 interactions from BioGRID

Brehme-Superti-Furga-2009 0.23%
Charting the molecular network of the drug target Bcr-Abl. Brehme et al (2009). Proc Natl Acad Sci U S A
Physical Interactions with 626 interactions from BioGRID

Jones-MacBeath-2006 0.23%
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Jones et al (2006). Nature
Physical Interactions with 158 interactions from iRefIndex

Scott-Schulman-2016 0.22%
Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Scott et al (2016). Cell
Physical Interactions with 111 interactions from BioGRID

Yang-Maurer-2018 0.22%
rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Yang et al (2018).
Nat Commun
Physical Interactions with 325 interactions from BioGRID

16 of 41
Physical Interactions 77.64%

Xu-Zetter-2016 0.22%
Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein. Xu et al (2016). J Mol
Cell Biol
Physical Interactions with 719 interactions from BioGRID

IREF-quickgo 0.22%
Physical Interactions with 9,985 interactions from iRefIndex

Van Quickelberghe-Gevaert-2018 0.22%

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Van Quickelberghe et al (2018). Sci
Data
Physical Interactions with 525 interactions from BioGRID

Mohammed-Carroll-2013 0.22%
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Mohammed et al (2013). Cell Rep
Physical Interactions with 112 interactions from BioGRID

IREF-intcomplex 0.22%
Physical Interactions with 212 interactions from iRefIndex

IREF-dip 0.21%
Physical Interactions with 5,037 interactions from iRefIndex

Yang-Wang-2018 0.21%
E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis. Yang et al (2018). J Invest
Dermatol
Physical Interactions with 103 interactions from iRefIndex

Tiemann-Kani-2019 0.21%
Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann et al (2019).
Oncogene
Physical Interactions with 339 interactions from BioGRID

IREF-mbinfo 0.21%
Physical Interactions with 113 interactions from iRefIndex

Wan-Emili-2015 0.21%
Panorama of ancient metazoan macromolecular complexes. Wan et al (2015). Nature
Physical Interactions with 16,627 interactions from BioGRID

Herr-Helleday-2015 0.20%
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Herr et
al (2015). Cell Discov
Physical Interactions with 117 interactions from iRefIndex

Gupta-Pelletier-2015 0.20%
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Gupta et al (2015). Cell
Physical Interactions with 306 interactions from BioGRID

Havugimana-Emili-2012 0.20%
A census of human soluble protein complexes. Havugimana et al (2012). Cell
Physical Interactions with 13,651 interactions from BioGRID

17 of 41
Physical Interactions 77.64%

Kaltenbach-Hughes-2007 0.20%
Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Kaltenbach et al (2007). PLoS Genet
Physical Interactions with 101 interactions from iRefIndex

Fonseca-Damgaard-2015 0.19%
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1
(mTORC1). Fonseca et al (2015). J Biol Chem
Physical Interactions with 105 interactions from BioGRID

Devarajan-Ketha-Kumar-2012 0.19%
The sclerostin-bone protein interactome. Devarajan-Ketha et al (2012). Biochem Biophys Res Commun
Physical Interactions with 99 interactions from BioGRID

Tang-Wang-2019 0.19%
The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang et al (2019).
Nat Commun
Physical Interactions with 294 interactions from BioGRID

Barrios-Rodiles-Wrana-2005 0.19%
High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles et al (2005). Science
Physical Interactions with 596 interactions from iRefIndex

Salvetti-Greco-2016 0.19%
Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches. Salvetti et al (2016). J Proteome Res
Physical Interactions with 144 interactions from BioGRID

Malinová-Verheggen-2017 0.19%
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. Malinová et al (2017). J Cell Biol
Physical Interactions with 2,778 interactions from BioGRID

Jeronimo-Coulombe-2007 0.19%
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK
capping enzyme. Jeronimo et al (2007). Mol Cell
Physical Interactions with 699 interactions from BioGRID

Choudhury-Michlewski-2017 0.19%
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury et al
(2017). BMC Biol
Physical Interactions with 250 interactions from BioGRID

Lu-Bohr-2017 0.19%
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.
Lu et al (2017). Nat Commun
Physical Interactions with 1,312 interactions from BioGRID

Hubel-Pichlmair-2019 0.19%
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Hubel et al (2019). Nat
Immunol
Physical Interactions with 2,707 interactions from BioGRID

Moon-Kim-2014 0.18%
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-

18 of 41
Physical Interactions 77.64%
Moon-Kim-2014
mass spectrometry. Moon et al (2014). Sci Rep
Physical Interactions with 171 interactions from BioGRID

Woods-Monteiro-2012 A 0.18%
Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods et al (2012). Sci Signal
Physical Interactions with 602 interactions from BioGRID

Rowbotham-Mermoud-2011 0.18%
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham et al
(2011). Mol Cell
Physical Interactions with 114 interactions from BioGRID

Loch-Strickler-2012 0.18%
A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.
Loch et al (2012). Biochim Biophys Acta
Physical Interactions with 145 interactions from BioGRID

Rosenbluh-Hahn-2016 0.18%
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active
Cancers. Rosenbluh et al (2016). Cell Syst
Physical Interactions with 3,482 interactions from BioGRID

Liebelt-Vertegaal-2020 0.18%
Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.
Liebelt et al (2020). Nucleic Acids Res
Physical Interactions with 100 interactions from BioGRID

Noguchi-Kawahara-2018 0.18%
ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Noguchi et al (2018). Biol
Open
Physical Interactions with 143 interactions from iRefIndex

Gilmore-Washburn-2016 0.18%
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. Gilmore et al (2016). PLoS
One
Physical Interactions with 944 interactions from BioGRID

Agrawal-Sedivy-2010 0.17%
Proteomic profiling of Myc-associated proteins. Agrawal et al (2010). Cell Cycle
Physical Interactions with 105 interactions from BioGRID

Cai-Conaway-2007 0.17%
YY1 functions with INO80 to activate transcription. Cai et al (2007). Nat Struct Mol Biol
Physical Interactions with 106 interactions from BioGRID

Lee-Mayr-2019 0.17%
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Lee et al (2019). Mol Cell
Physical Interactions with 1,759 interactions from BioGRID

Lee-Jeong-2017 0.17%
FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability. Lee et al (2017). FEBS Lett

19 of 41
Physical Interactions 77.64%
Lee-Jeong-2017
Physical Interactions with 100 interactions from iRefIndex

Oláh-Ovádi-2011 0.17%
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
Oláh et al (2011). J Biol Chem
Physical Interactions with 1,854 interactions from BioGRID

Roewenstrunk-de la Luna-2019 0.17%

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.
Roewenstrunk et al (2019). Sci Rep
Physical Interactions with 116 interactions from BioGRID

Mugabo-Lim-2018 0.17%
Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo et al (2018). J
Biol Chem
Physical Interactions with 111 interactions from BioGRID

Shami Shah-Baskin-2019 0.16%

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Shami Shah et al
(2019). Cell Rep
Physical Interactions with 2,927 interactions from BioGRID

Yao-Stagljar-2017 A 0.16%
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao et al (2017). Mol Cell
Physical Interactions with 312 interactions from BioGRID

Emdal-Olsen-2015 0.16%
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell
differentiation. Emdal et al (2015). Sci Signal
Physical Interactions with 1,917 interactions from BioGRID

Zhang-Wheeler-2014 0.16%
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in
pancreatic β cells. Zhang et al (2014). Mol Cell Proteomics
Physical Interactions with 93 interactions from BioGRID

Tong-Moran-2014 0.16%
Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated
with receptor endocytosis in response to EGF and stress. Tong et al (2014). Mol Cell Proteomics
Physical Interactions with 321 interactions from BioGRID

Yue-Liu-2018 0.16%
VIRMA mediates preferential m⁶A mRNA methylation in 3'UTR and near stop codon and associates with
alternative polyadenylation. Yue et al (2018). Cell Discov
Physical Interactions with 1,502 interactions from BioGRID

Papp-Lamia-2015 0.15%
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp et al (2015). Elife
Physical Interactions with 158 interactions from iRefIndex

Cheng-DeCaprio-2017 0.15%
Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. Cheng et al (2017). PLoS Pathog

20 of 41
Physical Interactions 77.64%
Cheng-DeCaprio-2017
Physical Interactions with 95 interactions from BioGRID

Ramachandran-LaBaer-2004 0.15%
Self-assembling protein microarrays. Ramachandran et al (2004). Science
Physical Interactions with 123 interactions from iRefIndex

Low-Heck-2014 0.15%
A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase. Low et al (2014). Sci Signal
Physical Interactions with 221 interactions from BioGRID

Liu-Takahashi-2017 0.15%
TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Liu et al (2017). Oncogene
Physical Interactions with 105 interactions from iRefIndex

Roy-Pardo-2014 0.15%
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Roy et al (2014).
Nucleic Acids Res
Physical Interactions with 386 interactions from BioGRID

Li-Dorf-2011 A 0.15%
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li et al (2011).
Immunity
Physical Interactions with 400 interactions from BioGRID

Giannone-Liu-2010 0.14%
The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone et al (2010).
PLoS One
Physical Interactions with 288 interactions from BioGRID

Choi-Busino-2018 0.14%
PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. Choi et al (2018). Cell Cycle
Physical Interactions with 1,087 interactions from BioGRID

Meek-Piwnica-Worms-2004 0.14%
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. Meek et al (2004). J Biol Chem
Physical Interactions with 328 interactions from iRefIndex

Wang-Balch-2006 0.14%
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Wang et al (2006). Cell
Physical Interactions with 200 interactions from BioGRID

Lum-Cristea-2018 0.14%
Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Lum et al
(2018). Cell Syst
Physical Interactions with 165 interactions from iRefIndex

IREF-uniprotpp 0.14%
Physical Interactions with 2,470 interactions from iRefIndex

Hu-Yin-2019 0.14%
Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents. Hu et al (2019).

21 of 41
Physical Interactions 77.64%
Hu-Yin-2019
EMBO Rep
Physical Interactions with 479 interactions from BioGRID

BIOGRID-SMALL-SCALE-STUDIES 0.14%
Physical Interactions with 79,201 interactions from BioGRID

Wallach-Kramer-2013 0.14%
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. Wallach et al (2013).
PLoS Genet
Physical Interactions with 143 interactions from BioGRID

Wu-Li-2007 0.14%
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu et al
(2007). Proteomics
Physical Interactions with 1,105 interactions from iRefIndex

Floyd-Pagliarini-2016 0.14%
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd et al (2016). Mol Cell
Physical Interactions with 1,508 interactions from BioGRID

Moutaoufik-Babu-2019 0.13%
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and
Neurogenesis. Moutaoufik et al (2019). iScience
Physical Interactions with 6,357 interactions from BioGRID

Sowa-Harper-2009 0.13%
Defining the human deubiquitinating enzyme interaction landscape. Sowa et al (2009). Cell
Physical Interactions with 1,509 interactions from BioGRID

Woodsmith-Sanderson-2012 0.13%
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination
networks. Woodsmith et al (2012). Mol Cell Proteomics
Physical Interactions with 206 interactions from iRefIndex

IREF-innatedb 0.13%
Physical Interactions with 2,355 interactions from iRefIndex

IREF-mppi 0.13%
Physical Interactions with 304 interactions from iRefIndex

Bennett-Harper-2010 0.13%
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett et al (2010). Cell
Physical Interactions with 4,362 interactions from BioGRID

Humphries-Humphries-2009 0.13%
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Humphries et al (2009).
Sci Signal
Physical Interactions with 1,060 interactions from BioGRID

McCracken-Blencowe-2005 0.12%
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. McCracken et al (2005). J Biol

22 of 41
Physical Interactions 77.64%
McCracken-Blencowe-2005
Chem
Physical Interactions with 198 interactions from BioGRID

Boldt-Roepman-2016 0.12%
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt et al (2016). Nat Commun
Physical Interactions with 4,898 interactions from BioGRID

Crow-Cristea-2017 0.12%
Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is
Counteracted by Virus-induced Proteasomal Degradation. Crow et al (2017). Mol Cell Proteomics
Physical Interactions with 180 interactions from iRefIndex

Alexander-Wang-2018 0.12%
Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation. Alexander et al (2018). Proc
Natl Acad Sci U S A
Physical Interactions with 189 interactions from iRefIndex

Arroyo-Aloy-2014 0.12%
Charting the molecular links between driver and susceptibility genes in colorectal cancer. Arroyo et al (2014). Biochem Biophys
Res Commun
Physical Interactions with 621 interactions from iRefIndex

Bett-Hay-2013 0.12%
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett et al (2013). Biochem J
Physical Interactions with 238 interactions from iRefIndex

Cox-Rizzino-2013 0.12%
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
Cox et al (2013). PLoS One
Physical Interactions with 190 interactions from iRefIndex

Pao-Virdee-2018 0.11%
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Pao et al (2018). Nature
Physical Interactions with 134 interactions from BioGRID

Bandyopadhyay-Ideker-2010 0.11%
A human MAP kinase interactome. Bandyopadhyay et al (2010). Nat Methods
Physical Interactions with 653 interactions from iRefIndex

Zhao-Krug-2005 0.11%
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular
pathways. Zhao et al (2005). Proc Natl Acad Sci U S A
Physical Interactions with 140 interactions from iRefIndex

Enzo-Dupont-2015 0.10%
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. Enzo et al (2015). EMBO J
Physical Interactions with 156 interactions from BioGRID

Huttlin-Harper-2017 0.10%
Architecture of the human interactome defines protein communities and disease networks. Huttlin et al (2017). Nature
Physical Interactions with 55,868 interactions from BioGRID

23 of 41
Physical Interactions 77.64%

Napolitano-Meroni-2011 0.10%
Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Napolitano et al (2011). Biochem J
Physical Interactions with 81 interactions from BioGRID

Varjosalo-Superti-Furga-2013 0.10%
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Varjosalo et al (2013). Nat
Methods
Physical Interactions with 484 interactions from BioGRID

Chi-Reed-2018 0.10%
Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains
multiple ALS/SMA-causative proteins. Chi et al (2018). Sci Rep
Physical Interactions with 456 interactions from BioGRID

Li-Lu-2018 0.10%
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li et al (2018).
Nat Commun
Physical Interactions with 176 interactions from iRefIndex

Viita-Vartiainen-2019 0.10%
Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. Viita et al (2019). J Cell
Sci
Physical Interactions with 213 interactions from BioGRID

Banks-Washburn-2016 0.09%
TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. Banks et al (2016). Mol Cell
Proteomics
Physical Interactions with 616 interactions from BioGRID

Tarallo-Weisz-2011 0.09%
Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem
affinity purification and nano LC-MS/MS. Tarallo et al (2011). Proteomics
Physical Interactions with 244 interactions from BioGRID

Yamauchi-Maeda-2018 0.09%
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by
DCPS. Yamauchi et al (2018). Cancer Cell
Physical Interactions with 261 interactions from iRefIndex

Douanne-Bidère-2019 0.09%
CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Douanne et al (2019). Cell Rep
Physical Interactions with 111 interactions from iRefIndex

Panigrahi-Pati-2012 0.09%
A cohesin-RAD21 interactome. Panigrahi et al (2012). Biochem J
Physical Interactions with 137 interactions from iRefIndex

Joshi-Cristea-2013 0.09%
The functional interactome landscape of the human histone deacetylase family. Joshi et al (2013). Mol Syst Biol
Physical Interactions with 375 interactions from BioGRID

Katsogiannou-Rocchi-2014 0.09%

24 of 41
Physical Interactions 77.64%
Katsogiannou-Rocchi-2014
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel
anticancer targets. Katsogiannou et al (2014). Mol Cell Proteomics
Physical Interactions with 221 interactions from iRefIndex

Trepte-Wanker-2018 A 0.09%
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions
in mammalian cells. Trepte et al (2018). Mol Syst Biol
Physical Interactions with 70 interactions from BioGRID

Lau-Ronai-2012 0.09%
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Lau et al
(2012). Cell
Physical Interactions with 102 interactions from iRefIndex

Campos-Reinberg-2015 0.09%
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Campos et al (2015). Mol Cell
Physical Interactions with 105 interactions from iRefIndex

Malty-Babu-2017 0.09%
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox
Homeostasis and NF-κB Signaling. Malty et al (2017). Cell Syst
Physical Interactions with 1,969 interactions from BioGRID

Roy-Parent-2013 0.09%
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Roy et al (2013). Mol
Endocrinol
Physical Interactions with 114 interactions from iRefIndex

Christianson-Kopito-2011 0.09%
Defining human ERAD networks through an integrative mapping strategy. Christianson et al (2011). Nat Cell Biol
Physical Interactions with 294 interactions from BioGRID

Li-Dorf-2014 0.09%
TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Li et al (2014). Proc Natl Acad Sci U S A
Physical Interactions with 495 interactions from BioGRID

Behrends-Harper-2010 0.09%
Network organization of the human autophagy system. Behrends et al (2010). Nature
Physical Interactions with 704 interactions from BioGRID

Drissi-Boisvert-2015 0.09%
Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular
Response to Etoposide Induced DNA Damage. Drissi et al (2015). Mol Cell Proteomics
Physical Interactions with 947 interactions from BioGRID

Foerster-Ritter-2013 0.08%
Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.
Foerster et al (2013). Proteomics
Physical Interactions with 179 interactions from BioGRID

Li-Chen-2015 0.08%

25 of 41
Physical Interactions 77.64%
Li-Chen-2015
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li et al (2015). Mol Syst Biol
Physical Interactions with 1,811 interactions from BioGRID

Lipp-Guthrie-2015 0.08%
SR protein kinases promote splicing of nonconsensus introns. Lipp et al (2015). Nat Struct Mol Biol
Physical Interactions with 388 interactions from BioGRID

IREF-mint 0.08%
Physical Interactions with 14,408 interactions from iRefIndex

Kennedy-Kolch-2020 A 0.08%
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D.
Kennedy et al (2020). Nat Commun
Physical Interactions with 4,232 interactions from BioGRID

IREF-corum 0.08%
Physical Interactions with 819 interactions from iRefIndex

Kärblane-Sarmiento-2015 0.07%
ABCE1 is a highly conserved RNA silencing suppressor. Kärblane et al (2015). PLoS One
Physical Interactions with 140 interactions from iRefIndex

Wong-O'Bryan-2012 0.07%
Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Wong et al (2012). PLoS One
Physical Interactions with 114 interactions from BioGRID

Li-Zhou-2017 0.07%
Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by
affinity proteomics. Li et al (2017). Oncogene
Physical Interactions with 104 interactions from iRefIndex

Wang-Xu-2015 0.07%
Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved
in metabolic and protein degradation pathways. Wang et al (2015). Neurobiol Aging
Physical Interactions with 197 interactions from BioGRID

Saito-Kobarg-2017 0.07%
Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. Saito et al (2017). J
Proteome Res
Physical Interactions with 165 interactions from iRefIndex

Dabbaghizadeh-Tanguay-2018 0.07%
Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster:
Implication in mitochondrial homeostasis. Dabbaghizadeh et al (2018). PLoS One
Physical Interactions with 144 interactions from BioGRID

Zhang-Xu-2018 0.07%
Revealing A-Raf functions through its interactome. Zhang et al (2018). Biochim Biophys Acta Proteins Proteom
Physical Interactions with 186 interactions from BioGRID

Hauri-Beisel-2016 0.07%

26 of 41
Physical Interactions 77.64%
Hauri-Beisel-2016
A High-Density Map for Navigating the Human Polycomb Complexome. Hauri et al (2016). Cell Rep
Physical Interactions with 1,216 interactions from BioGRID

Ewing-Figeys-2007 0.07%
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing et al (2007). Mol Syst Biol
Physical Interactions with 5,759 interactions from iRefIndex

Menon-Litovchick-2019 0.07%
DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. Menon et al
(2019). Cell Cycle
Physical Interactions with 119 interactions from BioGRID

IREF-bind-translation 0.07%
Physical Interactions with 6,056 interactions from iRefIndex

Hayes-Urbé-2012 0.06%
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase
and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. Hayes et al (2012). J Biol Chem
Physical Interactions with 110 interactions from BioGRID

Reyniers-Taymans-2014 0.06%
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. Reyniers et
al (2014). J Neurochem
Physical Interactions with 109 interactions from iRefIndex

Botham-Schimmer-2019 0.06%
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2. Botham
et al (2019). Proteomics
Physical Interactions with 317 interactions from BioGRID

Kim-Major-2015 0.06%
Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim et al (2015). Mol Cell Biol
Physical Interactions with 137 interactions from BioGRID

Grossmann-Stelzl-2015 0.06%
Phospho-tyrosine dependent protein-protein interaction network. Grossmann et al (2015). Mol Syst Biol
Physical Interactions with 620 interactions from BioGRID

IREF-bind 0.06%
Physical Interactions with 3,524 interactions from iRefIndex

Bouwmeester-Superti-Furga-2004 0.06%
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Bouwmeester et al (2004).
Nat Cell Biol
Physical Interactions with 1,694 interactions from iRefIndex

St-Denis-Gingras-2015 0.05%
Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper
abscission. St-Denis et al (2015). Mol Cell Proteomics
Physical Interactions with 168 interactions from BioGRID

0.05%
27 of 41
Physical Interactions 77.64%

Blomen-Brummelkamp-2015
Gene essentiality and synthetic lethality in haploid human cells. Blomen et al (2015). Science
Physical Interactions with 138 interactions from BioGRID

Li-Haura-2013 0.05%
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Li et al (2013). Mol Syst
Biol
Physical Interactions with 403 interactions from BioGRID

Liu-Chen-2019 0.05%
Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Liu et al (2019).
Cancer Med
Physical Interactions with 106 interactions from BioGRID

Liu-Yang-2019 0.05%
Inflammation-dependent overexpression of c-Myc enhances CRL4^DCAF4 E3 ligase activity and promotes
ubiquitination of ST7 in colitis-associated cancer. Liu et al (2019). J Pathol
Physical Interactions with 279 interactions from BioGRID

Oliviero-Cagney-2015 0.05%
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4,
a regulator of embryogenesis. Oliviero et al (2015). Sci Rep
Physical Interactions with 677 interactions from BioGRID

Huttlin-Gygi-2015 0.05%
The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin et al (2015). Cell
Physical Interactions with 23,384 interactions from BioGRID

Watanabe-Fujita-2018 0.05%
GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. Watanabe et al (2018). J Cell Sci
Physical Interactions with 158 interactions from iRefIndex

Hegele-Stelzl-2012 B 0.05%
Dynamic protein-protein interaction wiring of the human spliceosome. Hegele et al (2012). Mol Cell
Physical Interactions with 600 interactions from BioGRID

So-Colwill-2015 0.05%
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination
therapy. So et al (2015). Sci Signal
Physical Interactions with 652 interactions from BioGRID

Conte-Perez-Oliva-2018 0.05%
USP45 and Spindly are part of the same complex implicated in cell migration. Conte et al (2018). Sci Rep
Physical Interactions with 161 interactions from iRefIndex

Trepte-Wanker-2018 B 0.05%
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions
in mammalian cells. Trepte et al (2018). Mol Syst Biol
Physical Interactions with 138 interactions from BioGRID

Rual-Vidal-2005 0.04%
Towards a proteome-scale map of the human protein-protein interaction network. Rual et al (2005). Nature

28 of 41
Physical Interactions 77.64%
Rual-Vidal-2005
Physical Interactions with 4,031 interactions from iRefIndex

Liu-Tan-2018 0.04%
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Liu et al (2018). Nat
Commun
Physical Interactions with 331 interactions from BioGRID

IREF-matrixdb 0.04%
Physical Interactions with 15,422 interactions from iRefIndex

Huber-Hoelz-2017 0.04%
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber et al (2017). Proc Natl Acad Sci U S A
Physical Interactions with 217 interactions from iRefIndex

Teixeira-Laman-2016 A 0.04%
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira et al
(2016). Biochem J
Physical Interactions with 130 interactions from BioGRID

Coyaud-Raught-2015 0.04%
BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. Coyaud et al (2015). Mol Cell Proteomics
Physical Interactions with 164 interactions from BioGRID

Guard-Old-2019 0.04%
The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. Guard et al (2019). Sci Rep
Physical Interactions with 105 interactions from BioGRID

Rengasamy-Walsh-2017 0.04%
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. Rengasamy et al (2017). Nucleic
Acids Res
Physical Interactions with 103 interactions from iRefIndex

Bantscheff-Drewes-2011 0.04%
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff et al (2011). Nat
Biotechnol
Physical Interactions with 103 interactions from BioGRID

Asadi-Dhanvantari-2018 0.04%
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi et al
(2018). Front Endocrinol (Lausanne)
Physical Interactions with 229 interactions from BioGRID

Giurato-Tarallo-2018 0.04%
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato et al
(2018). Sci Data
Physical Interactions with 2,161 interactions from BioGRID

Rivera-Paes Leme-2018 0.04%

Agrin has a pathological role in the progression of oral cancer. Rivera et al (2018). Br J Cancer
Physical Interactions with 194 interactions from BioGRID

0.04%
29 of 41
Physical Interactions 77.64%

Yao-Stagljar-2017 B
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao et al (2017). Mol Cell
Physical Interactions with 325 interactions from BioGRID

Zeller-Wei-2006 0.04%
Global mapping of c-Myc binding sites and target gene networks in human B cells. Zeller et al (2006). Proc Natl Acad Sci U S A
Physical Interactions with 634 interactions from iRefIndex

Choi-Beutler-2019 0.04%
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi et al (2019). Science
Physical Interactions with 928 interactions from BioGRID

Pankow-Yates-2015 0.04%
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Pankow et al (2015). Nature
Physical Interactions with 637 interactions from BioGRID

Zhang-Zou-2011 0.04%
A bead-based approach for large-scale identification of in vitro kinase substrates. Zhang et al (2011). Proteomics
Physical Interactions with 163 interactions from iRefIndex

van Wijk-Timmers-2009 0.04%

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk et al (2009). Mol
Syst Biol
Physical Interactions with 322 interactions from iRefIndex

Scholz-Taylor-2016 0.03%
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Scholz et al (2016). PLoS Biol
Physical Interactions with 134 interactions from BioGRID

Abbasi-Schild-Poulter-2019 0.03%
Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. Abbasi et al (2019). J Proteome
Res
Physical Interactions with 166 interactions from iRefIndex

Pichlmair-Superti-Furga-2011 0.03%
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Pichlmair et al (2011). Nat Immunol
Physical Interactions with 99 interactions from BioGRID

Kahle-Zoghbi-2011 0.03%
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration
and ataxia. Kahle et al (2011). Hum Mol Genet
Physical Interactions with 132 interactions from iRefIndex

Wilkinson-Coba-2019 0.03%
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With
Neurodevelopmental Disorders. Wilkinson et al (2019). Biol Psychiatry
Physical Interactions with 100 interactions from iRefIndex

Woods-Monteiro-2012 B 0.03%
Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods et al (2012). Sci Signal
Physical Interactions with 325 interactions from BioGRID

30 of 41
Physical Interactions 77.64%

Cloutier-Coulombe-2017 0.03%
R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear
ribonucleoprotein. Cloutier et al (2017). Nat Commun
Physical Interactions with 506 interactions from BioGRID

Chen-Guan-2018 0.03%
SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Chen et al (2018). Cell Rep
Physical Interactions with 240 interactions from BioGRID

Kumar-Vertegaal-2017 0.03%
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar et al (2017). Nat
Commun
Physical Interactions with 1,198 interactions from BioGRID

Lim-Zoghbi-2006 0.03%
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim et al (2006).
Cell
Physical Interactions with 5,393 interactions from iRefIndex

Foster-Marshall-2013 0.03%
Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Foster et al (2013). Nitric Oxide
Physical Interactions with 111 interactions from iRefIndex

Xu-Ye-2012 0.03%
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-
associated degradation. Xu et al (2012). Cell Rep
Physical Interactions with 189 interactions from iRefIndex

Jin-Pawson-2004 0.03%
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and
cellular organization. Jin et al (2004). Curr Biol
Physical Interactions with 247 interactions from iRefIndex

Soler-López-Aloy-2011 0.02%
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Soler-López et al (2011). Genome Res
Physical Interactions with 283 interactions from iRefIndex

Rodriguez-von Kriegsheim-2016 0.02%

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Rodriguez et al (2016). Cell Rep
Physical Interactions with 2,035 interactions from BioGRID

IREF-spike 0.02%
Physical Interactions with 20,971 interactions from iRefIndex

Liu-Wang-2012 0.02%
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. Liu et al (2012).
J Proteome Res
Physical Interactions with 593 interactions from BioGRID

Chen-Yu-2018 0.02%
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen et al (2018).
Nat Genet

31 of 41
Physical Interactions 77.64%
Chen-Yu-2018
Physical Interactions with 404 interactions from BioGRID

Perez-Hernandez-Yáñez-Mó-2013 0.02%
The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes.
Perez-Hernandez et al (2013). J Biol Chem
Physical Interactions with 446 interactions from BioGRID

Sundell-Ivarsson-2018 0.02%
Proteome-wide analysis of phospho-regulated PDZ domain interactions. Sundell et al (2018). Mol Syst Biol
Physical Interactions with 129 interactions from iRefIndex

Hu-Woods-2019 0.02%
CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI. Hu et al (2019). Cell
Death Discov
Physical Interactions with 103 interactions from BioGRID

Wang-Yang-2011 0.02%
Toward an understanding of the protein interaction network of the human liver. Wang et al (2011). Mol Syst Biol
Physical Interactions with 3,408 interactions from BioGRID

Varjosalo-Gstaiger-2013 A 0.02%
The protein interaction landscape of the human CMGC kinase group. Varjosalo et al (2013). Cell Rep
Physical Interactions with 690 interactions from BioGRID

IREF-huri 0.02%
Physical Interactions with 47,604 interactions from iRefIndex

Yachie-Roth-2016 0.02%
Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie et al (2016). Mol Syst Biol
Physical Interactions with 671 interactions from BioGRID

Olma-Pintard-2009 0.01%
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.
Olma et al (2009). J Cell Sci
Physical Interactions with 213 interactions from BioGRID

Xie-Zhang-2017 0.01%
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Xie et al (2017). Nat
Commun
Physical Interactions with 227 interactions from BioGRID

Zhu-Liu-2018 0.01%
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell
carcinoma. Zhu et al (2018). Cancer Lett
Physical Interactions with 287 interactions from iRefIndex

Bogachek-Weigel-2014 0.01%
Sumoylation pathway is required to maintain the basal breast cancer subtype. Bogachek et al (2014). Cancer Cell
Physical Interactions with 134 interactions from iRefIndex

St-Denis-Gingras-2016 0.01%

32 of 41
Physical Interactions 77.64%
St-Denis-Gingras-2016
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis et al (2016). Cell
Rep
Physical Interactions with 783 interactions from BioGRID

Taipale-Lindquist-2014 0.01%
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale et al
(2014). Cell
Physical Interactions with 1,227 interactions from iRefIndex

Wang-Xiong-2019 0.01%
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang et al (2019). J
Clin Invest
Physical Interactions with 609 interactions from BioGRID

Pichlmair-Superti-Furga-2012 0.01%
Viral immune modulators perturb the human molecular network by common and unique strategies. Pichlmair et al (2012). Nature
Physical Interactions with 14 interactions from BioGRID

Miyamoto-Sato-Yanagawa-2010 0.01%
A comprehensive resource of interacting protein regions for refining human transcription factor networks. Miyamoto-Sato et al
(2010). PLoS One
Physical Interactions with 934 interactions from iRefIndex

Kawahara-Paes Leme-2017 0.01%

Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate. Kawahara et al (2017). J Proteomics
Physical Interactions with 114 interactions from BioGRID

Raman-Harper-2015 0.01%
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Raman et al
(2015). Nat Cell Biol
Physical Interactions with 271 interactions from BioGRID

Kumar-Maddika-2017 0.01%
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. Kumar et al (2017). J Proteome Res
Physical Interactions with 1,863 interactions from BioGRID

Ravasi-Hayashizaki-2010 0.01%
An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi et al (2010). Cell
Physical Interactions with 658 interactions from BioGRID

Li-Wang-2016 0.01%
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Li et al (2016). Mol Cell
Proteomics
Physical Interactions with 1,476 interactions from BioGRID

Blandin-Richard-2013 0.01%
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin et al
(2013). Skelet Muscle
Physical Interactions with 655 interactions from iRefIndex

Fragoza-Yu-2019 0.00%

33 of 41
Physical Interactions 77.64%
Fragoza-Yu-2019
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Fragoza et al (2019). Nat Commun
Physical Interactions with 603 interactions from iRefIndex

Liu-Sun-2019 0.00%
CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Liu et al (2019). Cell Death
Dis
Physical Interactions with 561 interactions from BioGRID

Ouyang-Gill-2009 0.00%
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang et al (2009). Mol Cell
Physical Interactions with 105 interactions from BioGRID

Albers-Koegl-2005 0.00%
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Albers et al (2005). Mol Cell Proteomics
Physical Interactions with 289 interactions from iRefIndex

Swayampakula-Dedhar-2017 0.00%
The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/
MMP14-mediated invasion. Swayampakula et al (2017). Oncogene
Physical Interactions with 126 interactions from iRefIndex

Sahni-Vidal-2015 0.00%
Widespread macromolecular interaction perturbations in human genetic disorders. Sahni et al (2015). Cell
Physical Interactions with 591 interactions from BioGRID

IREF-biogrid 0.00%
Physical Interactions with 176,314 interactions from iRefIndex

Cao-Chinnaiyan-2014 0.00%
The central role of EED in the orchestration of polycomb group complexes. Cao et al (2014). Nat Commun
Physical Interactions with 1,769 interactions from BioGRID

Co-expression 8.01%

Wang-Maris-2006 0.60%
Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional
alterations in DNA copy number. Wang et al (2006). Cancer Res
Co-expression with 270,388 interactions from GEO

Mallon-McKay-2013 0.51%
StemCellDB: the human pluripotent stem cell database at the National Institutes of Health. Mallon et al (2013). Stem Cell Res
Co-expression with 602,113 interactions from GEO

Roth-Zlotnik-2006 0.50%
Gene expression analyses reveal molecular relationships among 20 regions of the human CNS. Roth et al (2006). Neurogenetics
Co-expression with 683,844 interactions from GEO

Ramaswamy-Golub-2001 0.48%
Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al (2001). Proc Natl Acad Sci U S A

34 of 41
Co-expression 8.01%
Ramaswamy-Golub-2001
Co-expression with 284,829 interactions from supplementary material

Innocenti-Brown-2011 0.46%
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.
Innocenti et al (2011). PLoS Genet
Co-expression with 620,205 interactions from GEO

Alizadeh-Staudt-2000 0.46%
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Alizadeh et al (2000). Nature
Co-expression with 92,360 interactions from supplementary material

Dobbin-Giordano-2005 0.46%
Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Dobbin et al (2005).
Clin Cancer Res
Co-expression with 452,322 interactions from GEO

Rieger-Chu-2004 0.45%
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al (2004). Proc
Natl Acad Sci U S A
Co-expression with 266,879 interactions from GEO

Bild-Nevins-2006 B 0.44%
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al (2006). Nature
Co-expression with 285,368 interactions from GEO

Burington-Shaughnessy-2008 0.44%
Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to
survival in multiple myeloma. Burington et al (2008). Clin Cancer Res
Co-expression with 295,320 interactions from GEO

Boldrick-Relman-2002 0.39%
Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Boldrick et al (2002). Proc
Natl Acad Sci U S A
Co-expression with 116,197 interactions from supplementary material

Arijs-Rutgeerts-2009 0.39%
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs
et al (2009). PLoS One
Co-expression with 676,695 interactions from GEO

Jiang-de Kok-2017 0.36%

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-
induced liver injury. Jiang et al (2017). Toxicol Appl Pharmacol
Co-expression with 444,959 interactions from GEO

Perou-Botstein-2000 0.36%
Molecular portraits of human breast tumours. Perou et al (2000). Nature
Co-expression with 189,373 interactions from supplementary material

Chen-Brown-2002 0.35%
Gene expression patterns in human liver cancers. Chen et al (2002). Mol Biol Cell

35 of 41
Co-expression 8.01%
Chen-Brown-2002
Co-expression with 291,300 interactions from supplementary material

Wang-Cheung-2015 0.34%
Genetic variation in insulin-induced kinase signaling. Wang et al (2015). Mol Syst Biol
Co-expression with 422,896 interactions from GEO

Wu-Garvey-2007 0.28%
The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Wu et al (2007). Endocrine
Co-expression with 275,155 interactions from GEO

Rosenwald-Staudt-2001 0.28%
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. Rosenwald
et al (2001). J Exp Med
Co-expression with 118,097 interactions from supplementary material

Ross-Perou-2001 0.26%
A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines. Ross et al (2001). Dis Markers
Co-expression with 146,858 interactions from supplementary material

Perou-Botstein-1999 0.22%
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al (1999). Proc Natl Acad
Sci U S A
Co-expression with 68,200 interactions from supplementary material

Predicted 5.37%

I2D-Li-Vidal-2004-CE-DATA-Worm2Human 0.73%
A map of the interactome network of the metazoan C. elegans. Li et al (2004). Science
Predicted with 48 interactions from I2D

I2D-BioGRID-Yeast2Human 0.71%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 17,314 interactions from I2D

I2D-vonMering-Bork-2002-High-Yeast2Human 0.60%
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al (2002). Nature
Predicted with 723 interactions from I2D

I2D-Li-Vidal-2004-interolog-Worm2Human 0.51%
A map of the interactome network of the metazoan C. elegans. Li et al (2004). Science
Predicted with 396 interactions from I2D

I2D-vonMering-Bork-2002-Medium-Yeast2Human 0.40%
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al (2002). Nature
Predicted with 1,280 interactions from I2D

I2D-Tarassov-PCA-Yeast2Human 0.29%
An in vivo map of the yeast protein interactome. Tarassov et al (2008). Science
Predicted with 235 interactions from I2D

Wu-Stein-2010 0.24%

36 of 41
Predicted 5.37%
Wu-Stein-2010
A human functional protein interaction network and its application to cancer data analysis. Wu et al (2010). Genome Biol
Predicted with 89,967 interactions from supplementary material

I2D-vonMering-Bork-2002-Low-Yeast2Human 0.18%
Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al (2002). Nature
Predicted with 7,979 interactions from I2D

I2D-Wang-Orkin-2006-EScmplxIP-Mouse2Human 0.18%
A protein interaction network for pluripotency of embryonic stem cells. Wang et al (2006). Nature
Predicted with 5 interactions from I2D

I2D-IntAct-Mouse2Human 0.16%
The IntAct molecular interaction database in 2010. Aranda et al (2010). Nucleic Acids Res
Predicted with 11,478 interactions from I2D

I2D-INNATEDB-Mouse2Human 0.15%
InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Lynn et al (2008). Mol Syst Biol
Predicted with 4,049 interactions from I2D

I2D-BioGRID-Rat2Human 0.14%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 2,148 interactions from I2D

I2D-BioGRID-Mouse2Human 0.14%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 10,524 interactions from I2D

Stuart-Kim-2003 0.14%
A gene-coexpression network for global discovery of conserved genetic modules. Stuart et al (2003). Science
Predicted with 25,001 interactions from supplementary material

I2D-Yu-Vidal-2008-GoldStd-Yeast2Human 0.12%
High-quality binary protein interaction map of the yeast interactome network. Yu et al (2008). Science
Predicted with 173 interactions from I2D

I2D-Krogan-Greenblatt-2006-Core-Yeast2Human 0.10%
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan et al (2006). Nature
Predicted with 860 interactions from I2D

I2D-BioGRID-Fly2Human 0.09%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 8,676 interactions from I2D

I2D-BIND-Rat2Human 0.08%
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al
(2000). Bioinformatics
Predicted with 468 interactions from I2D

I2D-IntAct-Yeast2Human 0.08%
The IntAct molecular interaction database in 2010. Aranda et al (2010). Nucleic Acids Res

37 of 41
Predicted 5.37%
I2D-IntAct-Yeast2Human
Predicted with 7,325 interactions from I2D

I2D-IntAct-Rat2Human 0.08%
The IntAct molecular interaction database in 2010. Aranda et al (2010). Nucleic Acids Res
Predicted with 1,690 interactions from I2D

I2D-Chen-Pawson-2009-PiwiScreen-Mouse2Human 0.06%
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Chen et al (2009).
Proc Natl Acad Sci U S A
Predicted with 29 interactions from I2D

I2D-BIND-Mouse2Human 0.05%
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al
(2000). Bioinformatics
Predicted with 1,007 interactions from I2D

I2D-Krogan-Greenblatt-2006-NonCore-Yeast2Human 0.04%
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan et al (2006). Nature
Predicted with 678 interactions from I2D

I2D-MGI-Mouse2Human 0.04%
Ontological visualization of protein-protein interactions. Drabkin et al (2005). BMC Bioinformatics
Predicted with 595 interactions from I2D

I2D-MINT-Rat2Human 0.04%
MINT: a Molecular INTeraction database. Zanzoni et al (2002). FEBS Lett
Predicted with 540 interactions from I2D

I2D-BIND-Worm2Human 0.02%
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al
(2000). Bioinformatics
Predicted with 349 interactions from I2D

I2D-BIND-Yeast2Human 0.01%
BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al
(2000). Bioinformatics
Predicted with 599 interactions from I2D

I2D-Formstecher-Daviet-2005-Embryo-Fly2Human 0.00%
Protein interaction mapping: a Drosophila case study. Formstecher et al (2005). Genome Res
Predicted with 270 interactions from I2D

Co-localization 3.63%

Zhang-Shang-2006 1.44%
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. Zhang et al
(2006). EMBO J
Co-localization with 53 interactions from BioGRID

Schadt-Shoemaker-2004 1.11%
A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al
(2004). Genome Biol

38 of 41
Co-localization 3.63%
Schadt-Shoemaker-2004
Co-localization with 59,920 interactions from GEO

Johnson-Shoemaker-2003 0.71%
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Johnson et al (2003). Science
Co-localization with 426,464 interactions from GEO

Chen-Huang-2014 0.37%
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Chen et al (2014). J Proteome Res
Co-localization with 559 interactions from BioGRID

Genetic Interactions 2.87%

Shen-Mali-2017 0.32%
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Shen et al (2017). Nat Methods
Genetic Interactions with 152 interactions from BioGRID

Toyoshima-Grandori-2012 0.27%
Functional genomics identifies therapeutic targets for MYC-driven cancer. Toyoshima et al (2012). Proc Natl Acad Sci U S A
Genetic Interactions with 101 interactions from BioGRID

Matsuoka-Elledge-2007 0.25%
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka et al (2007). Science
Genetic Interactions with 342 interactions from iRefIndex

Vizeacoumar-Moffat-2013 0.25%
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al (2013). Mol
Syst Biol
Genetic Interactions with 201 interactions from BioGRID

Xie-Green-2012 0.23%
A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient
human cancer cells. Xie et al (2012). PLoS Genet
Genetic Interactions with 100 interactions from BioGRID

Srivas-Ideker-2016 0.23%
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Srivas et al (2016). Mol Cell
Genetic Interactions with 173 interactions from BioGRID

BIOGRID-SMALL-SCALE-STUDIES 0.22%
Genetic Interactions with 651 interactions from BioGRID

IREF-SMALL-SCALE-STUDIES 0.22%
Genetic Interactions with 1,159 interactions from iRefIndex

Han-Bassik-2017 A 0.22%
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Han et al (2017). Nat
Biotechnol
Genetic Interactions with 1,042 interactions from BioGRID

Du-Krogan-2017 0.11%

39 of 41
Genetic Interactions 2.87%
Du-Krogan-2017
Genetic interaction mapping in mammalian cells using CRISPR interference. Du et al (2017). Nat Methods
Genetic Interactions with 166 interactions from BioGRID

Horlbeck-Gilbert-2018 A 0.11%
Mapping the Genetic Landscape of Human Cells. Horlbeck et al (2018). Cell
Genetic Interactions with 1,808 interactions from BioGRID

Horlbeck-Gilbert-2018 B 0.10%
Mapping the Genetic Landscape of Human Cells. Horlbeck et al (2018). Cell
Genetic Interactions with 946 interactions from BioGRID

Blomen-Brummelkamp-2015 0.09%
Gene essentiality and synthetic lethality in haploid human cells. Blomen et al (2015). Science
Genetic Interactions with 127 interactions from BioGRID

Han-Bassik-2017 B 0.07%
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Han et al (2017). Nat
Biotechnol
Genetic Interactions with 893 interactions from BioGRID

Willingham-Muchowski-2003 0.06%
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham et al (2003). Science
Genetic Interactions with 37 interactions from BioGRID

Xiao-Brown-2018 0.06%
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao et al (2018). Proc
Natl Acad Sci U S A
Genetic Interactions with 684 interactions from BioGRID

Achuthankutty-Mailand-2019 0.03%
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. Achuthankutty et al
(2019). J Cell Biol
Genetic Interactions with 99 interactions from BioGRID

Luo-Elledge-2009 0.03%
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo et al (2009). Cell
Genetic Interactions with 316 interactions from BioGRID

Lin-Smith-2010 0.01%
A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes. Lin et al (2010). Genome Res
Genetic Interactions with 4,805,334 interactions from supplementary material

Pathway 1.88%

Wu-Stein-2010 0.60%
A human functional protein interaction network and its application to cancer data analysis. Wu et al (2010). Genome Biol
Pathway with 78,117 interactions from supplementary material

NCI_NATURE 0.39%
Pathway with 10,118 interactions from Pathway Commons

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Pathway 1.88%

REACTOME 0.38%
Pathway with 24,890 interactions from Pathway Commons

IMID 0.27%
Pathway with 1,023 interactions from Pathway Commons

CELL_MAP 0.23%
Pathway with 397 interactions from Pathway Commons

HUMANCYC 0.01%
Pathway with 681 interactions from Pathway Commons

Shared protein domains 0.60%

INTERPRO 0.39%
Shared protein domains with 621,159 interactions from InterPro

PFAM 0.21%
Shared protein domains with 471,533 interactions from Pfam

41 of 41