Project Phase I
A CMOS Diaphragm Based Label-Free DNA SoC Detection with Improved Sensitivity & Efficiency
Presented by: Shabaz Ahmed Sheikh.SS M Tech [Electronics], 2nd Year 12304013
Under The Guidance of Dr T Shanmuganantham Asst.Professor
Dept Of Electronics Engineering, Pondicherry University, Puducherry
Dept. of Electronics Engg. Pondicherry University
7/31/2013
Out Line
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o Motivation
o Objective
o Existing Model o Problems In Existing Model o Proposed Model o Expected improvement in proposed model
o Work Plan
o References
Dept. of Electronics Engg. Pondicherry University
7/31/2013
Motivation
3
DEOXYRIBONUCLEIC acid (DNA) detection is an important analytical method in molecular biology, and it finds a wide range of applications from genetic disease diagnostics, medicine and drug discovery, to forensic investigation and food testing, etc. This way we can and will be able to diagnose and detect the fatal diseases like HEPATITIS, CANCER, TB hands on without any special technique required .
This if done on a large scale can bring down the cost of this Lab-On-Chip device
drastically and will be boon to the mankind.
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
Objective
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To design a CMOS Diaphragm Based Label-Free DNA SoC
Detection with Improved Sensitivity & Efficiency
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
Existing Model
5
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
Existing Model Contd
6
Dept. of Electronics Engg. Pondicherry University
7/31/2013
Problems In Existing Model
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Resistance based .(piezoresistive)
Sensitivity can further be improved.
Interference due to unspecific binding. Communication/data rate to external wireless can be
improved. Power consumption can further be reduced.
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
Proposed model
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Capacitance based,i.e diaphragm will be used by iterating
different material combinations
Resistance to frequency
converter will be
replaced by
capacitive converter
QPSK system will be used instead of OOK for external
communication
Dept. of Electronics Engg. Pondicherry University
7/31/2013
Expected Improvements In Proposed Model
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Better sensitivity and detection
Lower power consumption
Higher data rate
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
Work Plan
Task
T1: Definition and plan
Subtask
Problem methodology plan
Duration
definition, July1-july25 10 and work
Expected Result
Study of A CMOS Membrane/Diaphragm Based Label-Free DNA SoC Detection Easy disease diagnosis eg. CANCER,HEPATITIS,TB, Avian Flu The methodology of design new capacitance or membrane based DNA detection Description about the tool to simulate the model The parameters and the values of input voltage used to simulate the model The expected result for proposed model Report submission for the work so far done Explanations for the queries regarding the work 7/31/2013 so far done
T2: Application
Identifying the applications July26-August10
T3: Proposal of A T3.1:Theoretical analysis August11- August 30 CMOS diaphragm based of existing model label-free DNA soc detection with improved sensitivity & efficiency T4.1: Choice of August 31- September 10 simulation tool T4.2: Simulation Sept 11- Oct 1 T4: Simulations conditions
T5: Presentations/ submissions
Dept. of Electronics Engg.
T4.3: Simulations of the Oct 02- Oct 15 proposed model. Oct 25 - Nov 25 T5.1: Report 1 Nov 9- Nov 30 T5.2: viva 1
Pondicherry University
References
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[1] Y.-J. Huang, C.-T. Lin, L.-G. Chen, P.-Y. Hsiao, B.-R.Wu, H.-T. Hsueh, B.-J. Kuo, H.-H. Tsai, H.-H. Liao, Y.-Z. Juang, C.-K. Wang, and S.-S. Lu, A fully-integrated cantilever-based DNA detection SoC in a CMOS bio MEMS process, in Proc. IEEE Symp. VLSI Circuits, 2011, pp. 5051. C.-W. Huang, T.-H. Lin, [2] N. Gemma, S. Ouchi, H. Funaki, J. Okada, and S. Hongo, CMOS integrated DNA chip for quantitative DNA analysis, in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560561. [3] S.-J. Kim and E. Yoon, Label-free CMOS biosensor with on-chip noise reduction scheme for realtime quantitative monitoring of biomolecules, IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 3, pp. 189196, Jun. 2012. [4] N. Lajnef, S. Chakrabartty, N. Elvin, and A. Elvin, Piezo-powered floating gate injector for selfpowered fatigue monitoring in biomechanical implants, in Proc. IEEE Int. Symp. Circuits and Systems, 2007, pp. 8992. [5] N. Gemma, S. Ouchi, H. Funaki, J. Okada, and S. Hongo, CMOS integrated DNA chip for quantitative DNA analysis, in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560561.
Dept. of Electronics Engg.
Pondicherry University
7/31/2013
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Dept. of Electronics Engg.
Pondicherry University
7/31/2013
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Dept. of Electronics Engg.
Pondicherry University
7/31/2013
