Here's a common code to find the last used cell in a column. This will use column A for example...
LR = Cells(Rows.Count, "A").End(xlup).Row
LR is now a variable represinting the Row # of the last used cell in column A
Now you can use that variable in a range statement like this
Range("A1:A" & LR)
Range("E" & Cells.Rows.Count).End(xlUp).Select
will select the last non-empty cell in Col E
Range("E1").Resize(Cells(Rows.Count,"E").End(xlUp).Row,1).Select