Miscellaneous Qqns DRUG DEVELOPMENT
review of pharmacology
193. Type A (augmented) adverse drug reactions are
characterized by all EXCEPT: (Karnataka 2007)
(a) Qualitatively abnormal responses to the drug
(b) Predictable from the drug’s known pharmacological or
toxicological effects
(c) Generally, dose-dependent
(d) Usually, common
194. In pregnancy, all of the following drugs are
contraindicated except: (AIIMS May 2011)
(a) ACE Inhibitors
(b) Angiotensin Receptor Blockers
(c) Propylthiouracil
(d) Thalidomide
195. A newborn baby was born with phocomelia. It
results due to which drug taken by mother during
pregnancy?
(a) Tetracycline (AIIMS Nov 2010)
(b) Thalidomide
(c) Warfarin
(d) Alcohol
196. Which of the following drugs can be given safely in
pregnancy: (AI 2009)
(a) Propylthiouracil
(b) Methotrexate
(c) Warfarin
(d) Tetracycline
197. All of the following drugs undergo hepatic
metabolism before excretion except: (AI 2002)
(a) Phenytoin
(b) Diazepam
(c) Penicillin G
(d) Cimetidine
198. All the following drugs can cross placenta except:
(a) Phenytoin (AI 2002)
(b) Diazepam
(c) Morphine
(d) Heparin
199. All are reasons for alteration of drug dosage in the
elderly except: (AI 2001, AIIMS May 2002)
(a) They have decreasing renal function with age
(b) They are lean and their body mass is less
(c) Have increased baroreceptor sensitivity
(d) Body water is decreased
200. True about the teratogenicity of a drug is all except:
(a) Characteristic set of malformations indicating
selectivity for certain target organs is seen (AI 2000)
(b) Heparin is highly teratogenic drug
(c) Related to the dose of the teratogenic drug
(d) Affects specifically at a particular phase of
development of the fetus
201. Side effects of a drug arise due to interactions of the
drug to molecules other than the target. These effects of
the drug can be minimized by its high:
(a) Specificity (AIIMS Nov., 2005)
(b) Solubility
(c) Affinity
(d) Hydrophobicity
202. Receptor mediated action is not seen in: (PGI June,
2004)
(a) Alcohol
(b) Antipsychotic
(c) Antacids
(d) Benzodiazepines
(e) Propofol
203. Blood brain barrier is crossed by: (PGI Dec. 2002)
(a) Dopamine
(b) Propranolol
(c) Glycopyrrolate
(d) Physostigmine
(e) Streptomycin
204. Drugs that can be safely given in pregnancy are:
(a) Antifolate (PGI Dec. 2002)
(b) Quinine
(c) Chloroquine
(d) Primaquine
(e) Tetracycline
205. Which of the following drugs are secreted in breast
milk? (PGI June, 2001)
(a) Antihistamines
(b) Antithyroid drugs
(c) Penicillin ALL
(d) Diazepam
(e) Antiepileptics
Phhaarrmmaaccoolologgyy
206. Which of the following drugs should be given in
sustained release oral dosage form?
(a) An anti-arrhythmic drug with a plasma half life of 10
seconds used for acute treatment of PSVT
(b) An anti-inflammatory drug with a plasma half life of 24hr
(c) A hypnotic drug with a plasma half life of 2 hours
(d) An antihypertensive with a plasma half life of 3 hours
207. Which of the following statements regarding
transfer of drugs across placenta is FALSE? (DPG-2007)
(a) Transfer across placenta is lesser in early pregnancy
(b) All drugs to some extent can cross the placenta
except heparin and insulin
(c) Ion trapping of acidic drugs occur in the placenta
(d) P-glycoprotein is present in placenta
208. Which of the following is excreted in saliva? (UP
2005)
(a) Tetracyclines
(b) Ampicillin
(c) Lithium
(d) Chloramphenicol
209. The pharmacokinetics change occurring in
geriatric patients is decline in: (UP 2005)
(a) Gastric absorption
(b) Liver metabolism
(c) Renal clearance
(d) Hypersensitivity
210. Drugs used for rare disease are known as: (TN 2007)
(a) Orphan drugs
(b) Rare drugs
(c) Over the counter drugs
(d) Emergency drugs
211. All these drugs EXCEPT one cross the blood-brain
barrier: (Karnataka 2007)
(a) Morphine
(b) Dopamine
(c) Propranolol
(d) Ether
212. The term physical half-life is applicable to:
(a) Repository preparations (Karnataka 2004)
(b) Prodrugs
(c) Radioactive isotopes
(d) Alkylating agents
213. Which of the following does not cross blood brain
barrier? (Karnataka 2003)
(a) Glycopyrrolate
(b) Atropine
(c) Scopolamine
(d) Promethazine
214. The following are given intradermally EXCEPT:
(a) Test dose of drugs (DPG 2008)
(b) Insulin
(c) BCG vaccine
(d) Mantoux test
