This document provides 14 lessons and hacks for building native and mobile web applications using JavaScript. It discusses issues like architecting for multiple platforms and environments, structuring the codebase, detecting the platform, improving performance of animations through CSS transitions, handling garbage collection of images and HTML, supporting touch events, adding sound, and leveraging tools like PhoneGap Build. The tips aim to help developers apply their web skills to build applications that run on both desktop and mobile devices using a single codebase.