Pandas is a Python package used for working with tabular data and performing data analysis. The core data structures in pandas are Series (one-dimensional) and DataFrame (two-dimensional). A DataFrame can be created from various data sources like lists, dictionaries, NumPy arrays, and other DataFrames. Some key operations on DataFrames include viewing data, handling duplicates, describing variable types and distributions, and loading/saving data from files like CSVs and JSONs.